Tbio CD59 CD59 glycoprotein

Protein Summary

Description

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P13987

Gene Name

• CD59

Ensembl ID

• ENST00000351554
• ENSP00000340210
• ENSG00000085063
• ENST00000395850
• ENSP00000379191
• ENST00000415002
• ENSP00000404822
• ENST00000426650
• ENSP00000402425
• ENST00000437761
• ENSP00000410182
• ENST00000445143
• ENSP00000403511
• ENST00000527577
• ENSP00000432942
• ENST00000642928
• ENSP00000494884

Symbol

• MIC11
• MIN1
• MIN2
• MIN3
• MSK21
• 1F5
• EJ16
• EJ30
• EL32
• G344
• MIN1
• MIN2
• MIN3
• MIRL
• HRF20
• MACIF
• MEM43
• MIC11
• MSK21
• 16.3A5
• HRF-20
• MAC-IP
• p18-20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
virus perturbation	0.99
transcription factor perturbation	0.96
kinase perturbation	0.93
biological term	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1236.6   (req: < 5)

Gene RIFs: 117   (req: <= 3)

Antibodies: 1684   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1236.6   (req: >= 5)

Gene RIFs: 117   (req: > 3)

Antibodies: 1684   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (350)

Explore Interacting Targets

1 – 10 of 350

• See Interactions on String-DB

PDCD2

Tbio

Novelty:  0.05054811

p_int:  0.997968548

p_ni:  0.002031425

p_wrong:  2.7e-8

Data Source:  BioPlex

SPINK1

Tbio

Family:  Enzyme

Novelty:  0.00074416

p_int:  0.977193187

p_ni:  0.022515311

p_wrong:  0.000291502

Data Source:  BioPlex

RABIF

Tbio

Novelty:  0.22512579

p_int:  0.965959443

p_ni:  0.034039364

p_wrong:  0.000001192

Data Source:  BioPlex

TINAGL1

Tbio

Novelty:  0.05578199

p_int:  0.955720646

p_ni:  0.003331773

p_wrong:  0.04094758

Score:  0.545

Data Source:  BioPlex,STRINGDB

PTP4A1

Tchem

Family:  Enzyme

Novelty:  0.02863007

p_int:  0.938298571

p_ni:  0.061700091

p_wrong:  0.000001339

Score:  0.199

Data Source:  BioPlex,STRINGDB

GCG

Tchem

Novelty:  0.00004879

p_int:  0.879632177

p_ni:  0.120185003

p_wrong:  0.000182819

Score:  0.186

Data Source:  BioPlex,STRINGDB

TMPRSS11B

Tdark

Family:  Enzyme

Novelty:  1.20690443

p_int:  0.852282449

p_ni:  0.000712903

p_wrong:  0.147004648

Data Source:  BioPlex

CD27

Tbio

Novelty:  0.00090508

p_int:  0.839629569

p_ni:  0.041981877

p_wrong:  0.118388554

Score:  0.393

Data Source:  BioPlex,STRINGDB

GALK2

Tbio

Family:  Kinase

Novelty:  0.06382824

p_int:  0.837174365

p_ni:  0.001243276

p_wrong:  0.161582359

Score:  0.209

Data Source:  BioPlex,STRINGDB

IGFBP1

Tchem

Novelty:  0.0006975

p_int:  0.806975429

p_ni:  0.056376253

p_wrong:  0.136648318

Score:  0.19

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (35)

Reactome (15)

KEGG (2)

PathwayCommons (1)

WikiPathways (17)

Asparagine N-linked glycosylation (R-HSA-446203)

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5

1 – 5 of 15

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Reactome	COPI-mediated anterograde transport	83 targets	R-HSA-6807878
Reactome	COPII-mediated vesicle transport	68 targets	R-HSA-204005
Reactome	Cargo concentration in the ER	33 targets	R-HSA-5694530
Reactome	Complement cascade	133 targets	R-HSA-166658

Name	Explore in Pharos	Explore in Source
Asparagine N-linked glycosylation	286 targets	R-HSA-446203
COPI-mediated anterograde transport	83 targets	R-HSA-6807878
COPII-mediated vesicle transport	68 targets	R-HSA-204005
Cargo concentration in the ER	33 targets	R-HSA-5694530
Complement cascade	133 targets	R-HSA-166658

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (23)

Functions (1)

Components (15)

Processes (7)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
complement binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	2	1	1	1.1	40.3
comparative body size at age 10, self-reported	EFO_0009819	1	1	1		28.1
biological sex	PATO_0000047	1	1	1		24.5
diet measurement	EFO_0008111	1	1	1		11

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	1	1.1	40.3
comparative body size at age 10, self-reported	EFO_0009819	1		28.1
biological sex	PATO_0000047	1		24.5
diet measurement	EFO_0008111	1		11

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Cell membrane
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycation
Glycoprotein
GPI-anchor
Hereditary hemolytic anemia

GWAS Trait Find Similar Targets

No Header	No Header
biological sex
chronotype measurement
comparative body size at age 10, self-reported
diet measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
mortality/aging
renal/urinary system phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	CD59 molecule (CD59 blood group)	VGNC:11287	739046
Mouse	CD59b antigen	MGI:1888996	333883
Mouse	CD59a antigen	MGI:109177	12509
Rat	CD59 molecule	RGD:2311	25407
Dog	CD59 molecule (CD59 blood group)		475945

Species	Name	OMA	EggNOG	Inparanoid
Chimp	CD59 molecule (CD59 blood group)
Mouse	CD59b antigen
Mouse	CD59a antigen
Rat	CD59 molecule
Dog	CD59 molecule (CD59 blood group)

Publication Statistics

PubMed Score 1236.60

PubMed score by year

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PubTator Score 18585.00

PubTator score by year

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Related Publications

Text Mined References (192)

GeneRif Annotations (117)

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10

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PMID	Year	Title