Protein Summary
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This pro ...more
- ENST00000351554
- ENSP00000340210
- ENSG00000085063
- ENST00000395850
- ENSP00000379191
- ENST00000415002
- ENSP00000404822
- ENST00000426650
- ENSP00000402425
- ENST00000437761
- ENSP00000410182
- ENST00000445143
- ENSP00000403511
- ENST00000527577
- ENSP00000432942
- ENST00000642928
- ENSP00000494884
- MIC11
- MIN1
- MIN2
- MIN3
- MSK21
- 1F5
- EJ16
- EJ30
- EL32
- G344
- MIN1
- MIN2
- MIN3
- MIRL
- HRF20
- MACIF
- MEM43
- MIC11
- MSK21
- 16.3A5
- HRF-20
- MAC-IP
- p18-20
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
virus perturbation | 0.99 | ||
transcription factor perturbation | 0.96 | ||
kinase perturbation | 0.93 | ||
biological term | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1236.6 (req: < 5)
Gene RIFs: 117 (req: <= 3)
Antibodies: 1684 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1236.6 (req: >= 5)
Gene RIFs: 117 (req: > 3)
Antibodies: 1684 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (350)
PDCD2
Novelty: 0.05054811
p_int: 0.997968548
p_ni: 0.002031425
p_wrong: 2.7e-8
Data Source: BioPlex
SPINK1
Family: Enzyme
Novelty: 0.00074416
p_int: 0.977193187
p_ni: 0.022515311
p_wrong: 0.000291502
Data Source: BioPlex
RABIF
Novelty: 0.22512579
p_int: 0.965959443
p_ni: 0.034039364
p_wrong: 0.000001192
Data Source: BioPlex
TINAGL1
Novelty: 0.05578199
p_int: 0.955720646
p_ni: 0.003331773
p_wrong: 0.04094758
Score: 0.545
Data Source: BioPlex,STRINGDB
PTP4A1
Family: Enzyme
Novelty: 0.02863007
p_int: 0.938298571
p_ni: 0.061700091
p_wrong: 0.000001339
Score: 0.199
Data Source: BioPlex,STRINGDB
GCG
Novelty: 0.00004879
p_int: 0.879632177
p_ni: 0.120185003
p_wrong: 0.000182819
Score: 0.186
Data Source: BioPlex,STRINGDB
TMPRSS11B
Family: Enzyme
Novelty: 1.20690443
p_int: 0.852282449
p_ni: 0.000712903
p_wrong: 0.147004648
Data Source: BioPlex
CD27
Novelty: 0.00090508
p_int: 0.839629569
p_ni: 0.041981877
p_wrong: 0.118388554
Score: 0.393
Data Source: BioPlex,STRINGDB
GALK2
Family: Kinase
Novelty: 0.06382824
p_int: 0.837174365
p_ni: 0.001243276
p_wrong: 0.161582359
Score: 0.209
Data Source: BioPlex,STRINGDB
IGFBP1
Novelty: 0.0006975
p_int: 0.806975429
p_ni: 0.056376253
p_wrong: 0.136648318
Score: 0.19
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (35)
Reactome (15)
KEGG (2)
PathwayCommons (1)
WikiPathways (17)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPI-mediated anterograde transport | ||||
Reactome | COPII-mediated vesicle transport | ||||
Reactome | Cargo concentration in the ER | ||||
Reactome | Complement cascade | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
COPI-mediated anterograde transport | ||||
COPII-mediated vesicle transport | ||||
Cargo concentration in the ER | ||||
Complement cascade | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (1)
Components (15)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
chronotype measurement | 2 | 1 | 1 | 1.1 | 40.3 | ||||
comparative body size at age 10, self-reported | 1 | 1 | 1 | 28.1 | |||||
biological sex | 1 | 1 | 1 | 24.5 | |||||
diet measurement | 1 | 1 | 1 | 11 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
chronotype measurement | 1 | 1.1 | 40.3 | ||||
comparative body size at age 10, self-reported | 1 | 28.1 | |||||
biological sex | 1 | 24.5 | |||||
diet measurement | 1 | 11 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | CD59 molecule (CD59 blood group) | VGNC:11287 | 739046 | |||||
Mouse | MGI:1888996 | 333883 | ||||||
Mouse | MGI:109177 | 12509 | ||||||
Rat | RGD:2311 | 25407 | ||||||
Dog | CD59 molecule (CD59 blood group) | 475945 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | CD59 molecule (CD59 blood group) | |||||
Mouse | ||||||
Mouse | ||||||
Rat | ||||||
Dog | CD59 molecule (CD59 blood group) | |||||
Publication Statistics
PubMed Score 1236.60
PubMed score by year
PubTator Score 18585.00
PubTator score by year
Related Publications
Text Mined References (192)
GeneRif Annotations (117)
Items per page:
0 of 0
PMID | Year | Title |
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