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Tbio
CD59
CD59 glycoprotein

Protein Summary
Description
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351554
  • ENSP00000340210
  • ENSG00000085063
  • ENST00000395850
  • ENSP00000379191
  • ENST00000415002
  • ENSP00000404822
  • ENST00000426650
  • ENSP00000402425
  • ENST00000437761
  • ENSP00000410182
  • ENST00000445143
  • ENSP00000403511
  • ENST00000527577
  • ENSP00000432942
  • ENST00000642928
  • ENSP00000494884

Symbol
  • MIC11
  • MIN1
  • MIN2
  • MIN3
  • MSK21
  • 1F5
  • EJ16
  • EJ30
  • EL32
  • G344
  • MIN1
  • MIN2
  • MIN3
  • MIRL
  • HRF20
  • MACIF
  • MEM43
  • MIC11
  • MSK21
  • 16.3A5
  • HRF-20
  • MAC-IP
  • p18-20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
0.99
transcription factor perturbation
0.96
kinase perturbation
0.93
biological term
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1225.45   (req: < 5)
Gene RIFs: 117   (req: <= 3)
Antibodies: 1684   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1225.45   (req: >= 5)
Gene RIFs: 117   (req: > 3)
Antibodies: 1684   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1
1
1.1
52.8
comparative body size at age 10, self-reported
1
1
1
18.7
diet measurement
1
1
1
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1.1
52.8
comparative body size at age 10, self-reported
1
18.7
diet measurement
1
2.6
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD59 molecule (CD59 blood group)
VGNC:11287
739046
Mouse
MGI:1888996
333883
Mouse
MGI:109177
12509
Rat
RGD:2311
25407
Dog
CD59 molecule (CD59 blood group)
475945
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD59 molecule (CD59 blood group)
Mouse
Mouse
Rat
Dog
CD59 molecule (CD59 blood group)
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P13987-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Reactome
Complement cascade
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
COPII-mediated vesicle transport
Cargo concentration in the ER
Complement cascade
Gene Ontology Terms (23)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (350)
1 – 10 of 350
PDCD2
Tbio
Novelty: 0.05054811
p_int: 0.997968548
p_ni: 0.002031425
p_wrong: 2.7e-8
Data Source: BioPlex
SPINK1
Tbio
Family: Enzyme
Novelty: 0.00074416
p_int: 0.977193187
p_ni: 0.022515311
p_wrong: 0.000291502
Data Source: BioPlex
RABIF
Tbio
Novelty: 0.22512579
p_int: 0.965959443
p_ni: 0.034039364
p_wrong: 0.000001192
Data Source: BioPlex
TINAGL1
Tbio
Novelty: 0.05578199
p_int: 0.955720646
p_ni: 0.003331773
p_wrong: 0.04094758
Score: 0.545
Data Source: BioPlex,STRINGDB
PTP4A1
Tchem
Family: Enzyme
Novelty: 0.02863007
p_int: 0.938298571
p_ni: 0.061700091
p_wrong: 0.000001339
Score: 0.199
Data Source: BioPlex,STRINGDB
GCG
Tchem
Novelty: 0.00004879
p_int: 0.879632177
p_ni: 0.120185003
p_wrong: 0.000182819
Score: 0.186
Data Source: BioPlex,STRINGDB
TMPRSS11B
Tdark
Family: Enzyme
Novelty: 1.20690443
p_int: 0.852282449
p_ni: 0.000712903
p_wrong: 0.147004648
Data Source: BioPlex
CD27
Tbio
Novelty: 0.00090508
p_int: 0.839629569
p_ni: 0.041981877
p_wrong: 0.118388554
Score: 0.393
Data Source: BioPlex,STRINGDB
GALK2
Tbio
Family: Kinase
Novelty: 0.06382824
p_int: 0.837174365
p_ni: 0.001243276
p_wrong: 0.161582359
Score: 0.209
Data Source: BioPlex,STRINGDB
IGFBP1
Tchem
Novelty: 0.0006975
p_int: 0.806975429
p_ni: 0.056376253
p_wrong: 0.136648318
Score: 0.19
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1225.45

PubMed score by year
PubTator Score  18585

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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