Protein Summary
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This pro ...more
- ENST00000351554
- ENSP00000340210
- ENSG00000085063
- ENST00000395850
- ENSP00000379191
- ENST00000415002
- ENSP00000404822
- ENST00000426650
- ENSP00000402425
- ENST00000437761
- ENSP00000410182
- ENST00000445143
- ENSP00000403511
- ENST00000527577
- ENSP00000432942
- ENST00000642928
- ENSP00000494884
- MIC11
- MIN1
- MIN2
- MIN3
- MSK21
- 1F5
- EJ16
- EJ30
- EL32
- G344
- MIN1
- MIN2
- MIN3
- MIRL
- HRF20
- MACIF
- MEM43
- MIC11
- MSK21
- 16.3A5
- HRF-20
- MAC-IP
- p18-20
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
virus perturbation | 0.99 | ||
transcription factor perturbation | 0.96 | ||
kinase perturbation | 0.93 | ||
biological term | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1386.01 (req: < 5)
Gene RIFs: 137 (req: <= 3)
Antibodies: 1684 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1386.01 (req: >= 5)
Gene RIFs: 137 (req: > 3)
Antibodies: 1684 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0