Tbio CD59 CD59 glycoprotein

Protein Summary

Description

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P13987

Gene Name

• CD59

Ensembl ID

• ENST00000351554
• ENSP00000340210
• ENSG00000085063
• ENST00000395850
• ENSP00000379191
• ENST00000415002
• ENSP00000404822
• ENST00000426650
• ENSP00000402425
• ENST00000437761
• ENSP00000410182
• ENST00000445143
• ENSP00000403511
• ENST00000527577
• ENSP00000432942
• ENST00000642928
• ENSP00000494884

Symbol

• MIC11
• MIN1
• MIN2
• MIN3
• MSK21
• 1F5
• EJ16
• EJ30
• EL32
• G344
• MIN1
• MIN2
• MIN3
• MIRL
• HRF20
• MACIF
• MEM43
• MIC11
• MSK21
• 16.3A5
• HRF-20
• MAC-IP
• p18-20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
virus perturbation	0.99
transcription factor perturbation	0.96
kinase perturbation	0.93
biological term	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1386.01   (req: < 5)

Gene RIFs: 133   (req: <= 3)

Antibodies: 1684   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1386.01   (req: >= 5)

Gene RIFs: 133   (req: > 3)

Antibodies: 1684   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0