Tbio GTF2F2 General transcription factor IIF subunit 2

Protein Summary

Description

TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.

Uniprot Accession IDs

• P13984
• A6NNS5
• Q5W0H3

Gene Name

• GTF2F2

Ensembl ID

• ENST00000340473
• ENSP00000340823
• ENSG00000188342

Symbol

• RAP30
• BTF4
• RAP30
• TF2F2
• TFIIF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.97
histone modification site profile	0.91
kinase perturbation	0.81
transcription factor binding site profile	0.81
cellular component	0.79

Protein Classes

PANTHER Classes

Protein / Transcription Factor / General Transcription Factor Iif Subunit 2

Protein / Nucleic Acid Binding / General Transcription Factor Iif Subunit 2

DTO Classes

Protein / Nucleic Acid Binding / General Transcription Factor Iif Subunit 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.24   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 255   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.24   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0