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Tclin
ADRB3
Beta-3 adrenergic receptor

Protein Summary
Description
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345060
  • ENSP00000343782
  • ENSG00000188778

Symbol
  • ADRB3R
  • B3AR
  • BETA3AR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
drug
0.85
molecular function
0.81
ligand (chemical)
0.8
chemical
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 918.11   (req: < 5)
Gene RIFs: 221   (req: <= 3)
Antibodies: 371   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 918.11   (req: >= 5)
Gene RIFs: 221   (req: > 3)
Antibodies: 371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1076
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13