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Tbio
ENO3
Beta-enolase

Protein Classes
Protein Summary
Description
Appears to have a function in striated muscle development and regeneration. This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323997
  • ENSP00000324105
  • ENSG00000108515
  • ENST00000518175
  • ENSP00000431087
  • ENST00000519584
  • ENSP00000430636

Symbol
  • MSE
  • GSD13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.87
protein domain
0.85
disease perturbation
0.83
transcription factor
0.79
gene perturbation
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 303.27   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 353   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 303.27   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 353   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
58.1
1
1
1
35.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
58.1
1
35.3
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (18)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (161)
1 – 10 of 161
ENO2
Tbio
Family: Enzyme
Novelty: 0.00016748
p_int: 1
Score: 0.962
Data Source: BioPlex,STRINGDB
ENO1
Tchem
Family: Enzyme
Novelty: 0.00109178
p_int: 0.999902403
p_ni: 0.000097597
Score: 0.962
Data Source: BioPlex,STRINGDB
PGAM1
Tbio
Family: Enzyme
Novelty: 0.0111272
Score: 0.994
Data Source: STRINGDB
PKM
Tchem
Family: Kinase
Novelty: 0.00076567
Score: 0.989
Data Source: STRINGDB
PKLR
Tbio
Family: Kinase
Novelty: 0.00268398
Score: 0.985
Data Source: STRINGDB
GPI
Tbio
Family: Enzyme
Novelty: 0.00095404
Score: 0.983
Data Source: STRINGDB
PGAM2
Tbio
Family: Enzyme
Novelty: 0.02438933
Score: 0.983
Data Source: STRINGDB
BPGM
Tbio
Family: Enzyme
Novelty: 0.03437401
Score: 0.963
Data Source: STRINGDB
TPI1
Tbio
Family: Enzyme
Novelty: 0.00074652
Score: 0.961
Data Source: STRINGDB
PCK2
Tbio
Family: Kinase
Novelty: 0.0035563
Score: 0.94
Data Source: STRINGDB
Publication Statistics
PubMed Score  303.27

PubMed score by year
PubTator Score  53.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer