Tbio ANXA8 Annexin A8

Protein Summary

Description

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P13928
• A6NDE6
• A6NLM1
• B4DKI1
• B4DTC9
• Q5T2P8
• Q5VTM4
• Q6GMY3
• Q9BT34

Gene Name

• ANXA8

Ensembl ID

• ENST00000577813
• ENSP00000463244
• ENSG00000265190
• ENST00000583911
• ENSP00000463091
• ENST00000585281
• ENSP00000462880

Symbol

• ANX8
• ANX8
• CH17-360D5.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1381.48   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1381.48   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0