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Tbio
ANXA8
Annexin A8

Protein Summary
Description
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000577813
  • ENSP00000463244
  • ENSG00000265190
  • ENST00000583911
  • ENSP00000463091
  • ENST00000585281
  • ENSP00000462880

Symbol
  • ANX8
  • ANX8
  • CH17-360D5.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1247.36   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1247.36   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P13928-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (39)
1 – 10 of 39
ACTA1
Tbio
Novelty:  0.00111813
p_int:  0.999999991
p_ni:  9e-9
Score:  0.638
Data Source:  BioPlex,STRINGDB
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.999957797
p_ni:  0.000042197
p_wrong:  6e-9
Data Source:  BioPlex
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.999809392
p_ni:  0.000032996
p_wrong:  0.000157612
Data Source:  BioPlex
PDE4DIP
Tbio
Novelty:  0.03414104
p_int:  0.999533454
p_ni:  0.000466544
p_wrong:  2e-9
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.965229406
p_ni:  0.000455751
p_wrong:  0.034314843
Data Source:  BioPlex
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.929662307
p_ni:  0.00048329
p_wrong:  0.069854403
Score:  0.214
Data Source:  BioPlex,STRINGDB
SRPX2
Tbio
Novelty:  0.01298081
Score:  0.805
Data Source:  STRINGDB
DYSF
Tbio
Novelty:  0.00248634
Score:  0.75
Data Source:  STRINGDB
HLF
Tbio
Family:  TF
Novelty:  0.03907097
Score:  0.741
Data Source:  STRINGDB
CD63
Tchem
Novelty:  0.00072515
Score:  0.674
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1247.36

PubMed score by year
PubTator Score  19.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer