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Tclin
SLC5A1
Sodium/glucose cotransporter 1

Protein Summary
Description
Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266088
  • ENSP00000266088
  • ENSG00000100170
  • ENST00000543737
  • ENSP00000444898

Symbol
  • NAGT
  • SGLT1
  • NAGT
  • SGLT1
  • D22S675
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
biological term
0.71
PubMedID
0.66
gene perturbation
0.62
cellular component
0.58


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 880.53   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 330   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 880.53   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 638
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Active Ligands (638)
1 – 10 of 638
CHEMBL245067
chemical structure image
CHEMBL450044
chemical structure image
CHEMBL1770245
chemical structure image
CHEMBL1770244
chemical structure image
CHEMBL1770246
chemical structure image
CHEMBL565376
chemical structure image
CHEMBL3931630
chemical structure image
CHEMBL566622
chemical structure image
CHEMBL565391
chemical structure image
CHEMBL2323689
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose tolerance test
2
2
2
87
glucose-dependent insulinotropic peptide measurement
1
1
1
64.2
glucagon-like peptide-1 measurement
1
1
1
31.8
diastolic blood pressure
1
1
1
3.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose tolerance test
2
87
glucose-dependent insulinotropic peptide measurement
1
64.2
glucagon-like peptide-1 measurement
1
31.8
diastolic blood pressure
1
3.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 1
VGNC:7804
458779
Macaque
solute carrier family 5 member 1
717070
Mouse
MGI:107678
20537
Rat
RGD:3713
25552
Dog
solute carrier family 5 member 1
VGNC:52969
492299
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 1
Macaque
solute carrier family 5 member 1
Mouse
Rat
Dog
solute carrier family 5 member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P13866-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (24)
Cellular hexose transport (R-HSA-189200)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular hexose transport
Reactome
Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)
Reactome
Digestion and absorption
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Name
Explore in Pharos
Explore in Source
Cellular hexose transport
Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)
Digestion and absorption
Disease
Disorders of transmembrane transporters
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (111)
1 – 10 of 111
SLC2A2
Tchem
Family: Transporter
Novelty: 0.00103579
Score: 0.913
Data Source: STRINGDB
SLC2A5
Tbio
Family: Transporter
Novelty: 0.0032733
Score: 0.851
Data Source: STRINGDB
MFSD4B
Tdark
Novelty: 0.03380333
Score: 0.834
Data Source: STRINGDB
SLC9A3
Tclin
Family: Transporter
Novelty: 0.00146466
Score: 0.807
Data Source: STRINGDB
SLC15A1
Tchem
Family: Transporter
Novelty: 0.00149723
Score: 0.804
Data Source: STRINGDB
TAS1R3
Tbio
Family: GPCR
Novelty: 0.00370936
Score: 0.801
Data Source: STRINGDB
TAS1R2
Tbio
Family: GPCR
Novelty: 0.00568766
Score: 0.801
Data Source: STRINGDB
GNAT3
Tbio
Novelty: 0.00702357
Score: 0.752
Data Source: STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.745
Data Source: STRINGDB
SLC2A1
Tchem
Family: Transporter
Novelty: 0.00027583
Score: 0.724
Data Source: STRINGDB
Publication Statistics
PubMed Score  880.53

PubMed score by year
PubTator Score  366.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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