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Tbio
PRKAR2A
cAMP-dependent protein kinase type II-alpha regulatory subunit

Protein Summary
Description
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265563
  • ENSP00000265563
  • ENSG00000114302
  • ENST00000296446
  • ENSP00000296446
  • ENST00000454963
  • ENSP00000394041

Symbol
  • PKR2
  • PRKAR2
  • PKR2
  • PRKAR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
biological process
0.93
protein domain
0.92
hub protein
0.88
pathway
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.83   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 402   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.83   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 402   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
66.1
depressive symptom measurement
2
1
2
54.3
intelligence
1
1
0
5.4
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
66.1
depressive symptom measurement
2
54.3
intelligence
0
5.4
11.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase cAMP-dependent type II regulatory subunit alpha
VGNC:12132
100613657
Macaque
cAMP-dependent protein kinase type II-alpha regulatory subunit
708981
Mouse
MGI:108025
19087
Rat
RGD:3393
29699
Dog
protein kinase cAMP-dependent type II regulatory subunit alpha
VGNC:44976
100685147
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase cAMP-dependent type II regulatory subunit alpha
Macaque
cAMP-dependent protein kinase type II-alpha regulatory subunit
Mouse
Rat
Dog
protein kinase cAMP-dependent type II regulatory subunit alpha
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P13861-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (71)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 38
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Aquaporin-mediated transport
Reactome
Axon guidance
Reactome
CREB1 phosphorylation through the activation of Adenylate Cyclase
Reactome
Ca-dependent events
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Aquaporin-mediated transport
Axon guidance
CREB1 phosphorylation through the activation of Adenylate Cyclase
Ca-dependent events
Gene Ontology Terms (26)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (185)
1 – 10 of 185
PRKAR2B
Tbio
Family: Enzyme
Novelty: 0.00456972
p_int: 0.999509391
p_ni: 0.000490609
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
AKAP14
Tbio
Family: Enzyme
Novelty: 0.50699923
p_int: 0.991103992
p_ni: 0.008896008
Score: 0.952
Data Source: BioPlex,STRINGDB
PRKACB
Tchem
Family: Kinase
Novelty: 0.01962222
p_int: 0.978499016
p_ni: 0.021500984
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
PRKACA
Tchem
Family: Kinase
Novelty: 0.03869658
Score: 0.997
Data Source: Reactome,STRINGDB
PRKACG
Tbio
Family: Kinase
Novelty: 0.11080061
Score: 0.993
Data Source: Reactome,STRINGDB
AKAP1
Tbio
Family: Epigenetic
Novelty: 0.00437217
Score: 0.97
Data Source: Reactome,STRINGDB
RUNX1T1
Tbio
Novelty: 0.0039633
Score: 0.964
Data Source: STRINGDB
AKAP5
Tbio
Family: Enzyme
Novelty: 0.00351101
Score: 0.963
Data Source: Reactome,STRINGDB
AKAP9
Tbio
Family: Enzyme
Novelty: 0.0106532
Score: 0.958
Data Source: STRINGDB
AKAP4
Tbio
Family: Enzyme
Novelty: 0.00760557
Score: 0.955
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.83

PubMed score by year
PubTator Score  6.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer