Tchem GYS1 Glycogen [starch] synthase, muscle

Protein Summary

Description

Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• P13807
• Q9BTT9

Gene Name

• GYS1

Ensembl ID

• ENST00000263276
• ENSP00000263276
• ENSG00000104812
• ENST00000323798
• ENSP00000317904

Symbol

• GYS
• GSY
• GYS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.93
hub protein	0.92
drug perturbation	0.87
histone modification site profile	0.85
tissue sample	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.67   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 331   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.67   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 105

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0