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Tchem
GYS1
Glycogen [starch] synthase, muscle

Protein Summary
Description
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263276
  • ENSP00000263276
  • ENSG00000104812
  • ENST00000323798
  • ENSP00000317904

Symbol
  • GYS
  • GSY
  • GYS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.93
hub protein
0.92
drug perturbation
0.87
histone modification site profile
0.85
tissue sample
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.96   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.96   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 101
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
39.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
39.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycogen synthase 1
VGNC:6631
456196
Macaque
glycogen synthase 1
574233
Mouse
MGI:101805
14936
Rat
RGD:1589798
690987
Dog
glycogen synthase 1
VGNC:41574
611993
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycogen synthase 1
Macaque
glycogen synthase 1
Mouse
Rat
Dog
glycogen synthase 1
Pathways (36)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Glycogen metabolism
Reactome
Glycogen storage disease type 0 (muscle GYS1)
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Glycogen metabolism
Glycogen storage disease type 0 (muscle GYS1)
Protein-Protein Interactions (151)
1 – 10 of 151
STBD1
Tbio
Novelty: 0.08362185
p_int: 0.999972166
p_ni: 0.000027834
Score: 0.849
Data Source: BioPlex,STRINGDB
GYG2
Tbio
Family: Enzyme
Novelty: 0.01520991
p_int: 0.999958277
p_ni: 0.000041723
Score: 0.996
Data Source: BioPlex,STRINGDB
GBE1
Tbio
Family: Enzyme
Novelty: 0.00233237
p_int: 0.999940564
p_ni: 0.000059436
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
AMY2A
Tclin
Family: Enzyme
Novelty: 0.00132709
p_int: 0.999674686
p_ni: 0.000325314
Score: 0.202
Data Source: BioPlex,STRINGDB
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00354658
p_int: 0.999096852
p_ni: 0.000903148
Score: 0.878
Data Source: BioPlex,STRINGDB
PPP1R3C
Tbio
Family: Enzyme
Novelty: 0.01784199
p_int: 0.997286599
p_ni: 0.002713401
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
PRKAB2
Tchem
Family: Enzyme
Novelty: 0.02815065
p_int: 0.991172489
p_ni: 0.008827511
Score: 0.905
Data Source: BioPlex,STRINGDB
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
p_int: 0.981728805
p_ni: 0.018271195
Score: 0.909
Data Source: BioPlex,STRINGDB
RASEF
Tbio
Novelty: 0.08877022
p_int: 0.91318636
p_ni: 0.08681364
Data Source: BioPlex
GYG1
Tbio
Family: Enzyme
Novelty: 0.01446978
Score: 0.995
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  147.96

PubMed score by year
PubTator Score  57.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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