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Tbio
ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

Protein Classes
Protein Summary
Description
Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:27499296, PubMed:15159392, PubMed:15975918, PubMed:9334218, PubMed:10356313). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1882842, PubMed:1430199). ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000433983
  • ENSP00000399273
  • ENSG00000140374
  • ENST00000557943
  • ENSP00000452762

Symbol
  • EMA
  • GA2
  • MADD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
transcription factor perturbation
0.94
interacting protein
0.85
protein domain
0.85
histone modification site profile
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 317.87   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 317.87   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Protein-Protein Interactions (183)
1 – 10 of 183
ETFRF1
Tdark
Novelty: 2
p_int: 1
Score: 0.919
Data Source: BioPlex,STRINGDB
ETFB
Tbio
Novelty: 0.03223782
p_int: 0.999999668
p_ni: 3.32e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
C8orf82
Tdark
p_int: 0.999877381
p_ni: 9.3e-8
p_wrong: 0.000122526
Score: 0.685
Data Source: BioPlex,STRINGDB
ETFDH
Tbio
Family: Enzyme
Novelty: 0.01405829
Score: 0.999
Data Source: Reactome,STRINGDB
ACADM
Tbio
Family: Enzyme
Novelty: 0.00590747
Score: 0.948
Data Source: STRINGDB
CYCS
Tchem
Novelty: 0.00018258
Score: 0.944
Data Source: STRINGDB
ECHS1
Tbio
Family: Enzyme
Novelty: 0.01956365
Score: 0.911
Data Source: STRINGDB
SUCLG2
Tbio
Family: Enzyme
Novelty: 0.0010641
Score: 0.898
Data Source: STRINGDB
NDUFAB1
Tclin
Novelty: 0.00207106
Score: 0.883
Data Source: STRINGDB
RAB6A
Tbio
Family: Enzyme
Novelty: 0.00718819
Score: 0.873
Data Source: STRINGDB
Publication Statistics
PubMed Score  317.87

PubMed score by year
PubTator Score  166.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer