Tbio ETFA Electron transfer flavoprotein subunit alpha, mitochondrial

Protein Summary

Description

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:27499296, PubMed:15159392, PubMed:15975918, PubMed:9334218, PubMed:10356313). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1882842, PubMed:1430199). ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P13804
• B4DT43
• Q53XN3
• Alpha-ETF

Gene Name

• ETFA

Ensembl ID

• ENST00000433983
• ENSP00000399273
• ENSG00000140374
• ENST00000557943
• ENSP00000452762

Symbol

• EMA
• GA2
• MADD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
transcription factor perturbation	0.94
interacting protein	0.85
protein domain	0.85
histone modification site profile	0.83

Protein Classes

PANTHER Classes

Protein / Transferase / Electron Transfer Flavoprotein Subunit Alpha, Mitochondrial

Protein / Oxidoreductase / Oxidase / Electron Transfer Flavoprotein Subunit Alpha, Mitochondrial

Protein / Oxidoreductase / Dehydrogenase / Electron Transfer Flavoprotein Subunit Alpha, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxidase / Electron Transfer Flavoprotein Subunit Alpha, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 701.36   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 341   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 701.36   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0