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Tbio
ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

Protein Classes
Protein Summary
Description
Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:27499296, PubMed:15159392, PubMed:15975918, PubMed:9334218, PubMed:10356313). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (PubMed:9334218). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:1882842, PubMed:1430199). ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000433983
  • ENSP00000399273
  • ENSG00000140374
  • ENST00000557943
  • ENSP00000452762

Symbol
  • EMA
  • GA2
  • MADD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
transcription factor perturbation
0.94
interacting protein
0.85
protein domain
0.85
histone modification site profile
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 526.36   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 526.36   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.4
79.9
1
1
0
1.4
66.8
heel bone mineral density
1
1
1
16.4
C-reactive protein measurement
1
1
1
14.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
79.9
0
1.4
66.8
heel bone mineral density
1
16.4
C-reactive protein measurement
1
14.1
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
electron transfer flavoprotein subunit alpha
VGNC:11866
453769
Macaque
electron transfer flavoprotein alpha subunit
707693
Mouse
MGI:106092
110842
Rat
RGD:628747
300726
Dog
electron transfer flavoprotein subunit alpha
VGNC:40487
610134
Species
Name
OMA
EggNOG
Inparanoid
Chimp
electron transfer flavoprotein subunit alpha
Macaque
electron transfer flavoprotein alpha subunit
Mouse
Rat
Dog
electron transfer flavoprotein subunit alpha
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P13804-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Protein-Protein Interactions (183)
1 – 10 of 183
ETFRF1
Tdark
Novelty: 1.28847105
p_int: 1
Score: 0.919
Data Source: BioPlex,STRINGDB
ETFB
Tbio
Novelty: 0.02010772
p_int: 0.999999668
p_ni: 3.32e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
C8orf82
Tdark
Novelty: 3.49514563
p_int: 0.999877381
p_ni: 9.3e-8
p_wrong: 0.000122526
Score: 0.685
Data Source: BioPlex,STRINGDB
ETFDH
Tbio
Family: Enzyme
Novelty: 0.00970137
Score: 0.999
Data Source: Reactome,STRINGDB
ACADM
Tbio
Family: Enzyme
Novelty: 0.00548721
Score: 0.948
Data Source: STRINGDB
CYCS
Tchem
Novelty: 0.00014004
Score: 0.944
Data Source: STRINGDB
ECHS1
Tbio
Family: Enzyme
Novelty: 0.01291476
Score: 0.911
Data Source: STRINGDB
SUCLG2
Tbio
Family: Enzyme
Novelty: 0.00094061
Score: 0.898
Data Source: STRINGDB
NDUFAB1
Tclin
Novelty: 0.00190242
Score: 0.883
Data Source: STRINGDB
RAB6A
Tbio
Family: Enzyme
Novelty: 0.00546034
Score: 0.873
Data Source: STRINGDB
Publication Statistics
PubMed Score  526.36

PubMed score by year
PubTator Score  166.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer