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Tchem
APEH
Acylamino-acid-releasing enzyme

Protein Summary
Description
This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296456
  • ENSP00000296456
  • ENSG00000164062

Symbol
  • D3F15S2
  • D3S48E
  • DNF15S2
  • APH
  • OPH
  • AARE
  • ACPH
  • D3S48E
  • D3F15S2
  • DNF15S2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
kinase perturbation
0.81
tissue sample
0.71
interacting protein
0.64
molecular function
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1157.18   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1157.18   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL2333026
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
76.2
household income
1
1
1
41
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
76.2
household income
1
41
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acylaminoacyl-peptide hydrolase
VGNC:8731
460376
Macaque
acylaminoacyl-peptide hydrolase
705948
Mouse
MGI:88041
235606
Rat
RGD:2125
24206
Dog
acylaminoacyl-peptide hydrolase
VGNC:37982
476622
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acylaminoacyl-peptide hydrolase
Macaque
acylaminoacyl-peptide hydrolase
Mouse
Rat
Dog
acylaminoacyl-peptide hydrolase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P13798-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Eukaryotic Translation Termination (R-HSA-72764)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Eukaryotic Translation Termination
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Eukaryotic Translation Termination
Immune System
Innate Immune System
Metabolism of proteins
Neutrophil degranulation
Protein-Protein Interactions (93)
1 – 10 of 93
PFKL
Tbio
Family: Kinase
Novelty: 0.00586306
Score: 0.862
Data Source: STRINGDB
ACY1
Tbio
Family: Enzyme
Novelty: 0.00912344
Score: 0.755
Data Source: STRINGDB
MSRA
Tbio
Family: Enzyme
Novelty: 0.00595154
Score: 0.753
Data Source: STRINGDB
MST1
Tbio
Family: Enzyme
Novelty: 0.00781564
Score: 0.751
Data Source: STRINGDB
PREP
Tchem
Family: Enzyme
Novelty: 0.00148266
Score: 0.706
Data Source: STRINGDB
CHMP2A
Tbio
Novelty: 0.00169253
Score: 0.7
Data Source: STRINGDB
RNF123
Tbio
Family: Enzyme
Novelty: 0.01872044
Score: 0.663
Data Source: STRINGDB
TRAIP
Tbio
Family: Enzyme
Novelty: 0.04163226
Score: 0.649
Data Source: STRINGDB
PSEN1
Tchem
Family: Enzyme
Novelty: 0.00024189
Score: 0.644
Data Source: STRINGDB
IP6K1
Tbio
Family: Kinase
Novelty: 0.03418032
Score: 0.642
Data Source: STRINGDB
Publication Statistics
PubMed Score  1157.18

PubMed score by year
PubTator Score  222.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer