APEH
Acylamino-acid-releasing enzyme
Protein Summary
This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small ...more
- ENST00000296456
- ENSP00000296456
- ENSG00000164062
- D3F15S2
- D3S48E
- DNF15S2
- APH
- OPH
- AARE
- ACPH
- D3S48E
- D3F15S2
- DNF15S2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.83 | ||
kinase perturbation | 0.81 | ||
tissue sample | 0.71 | ||
interacting protein | 0.64 | ||
molecular function | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1191.23 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 217 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1191.23 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 217 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (93)
Nearest Tclin Targets
Pathways (6)
Reactome (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Eukaryotic Translation Termination | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Eukaryotic Translation Termination | ||||
Immune System | ||||
Innate Immune System | ||||
Metabolism of proteins | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (4)
Components (5)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (37)
Items per page:
1 – 5 of 37
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 6 | 7 | 6 | 8.2 | 99.1 | ||||
mathematical ability | 4 | 5 | 6 | 98.5 | |||||
reticulocyte count | 2 | 3 | 3 | 96.4 | |||||
intelligence | 4 | 6 | 3 | 8.2 | 95.6 | ||||
household income | 2 | 5 | 6 | 93.3 | |||||
Items per page:
1 – 5 of 37
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 6 | 8.2 | 99.1 | ||||
mathematical ability | 6 | 98.5 | |||||
reticulocyte count | 3 | 96.4 | |||||
intelligence | 3 | 8.2 | 95.6 | ||||
household income | 6 | 93.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | acylaminoacyl-peptide hydrolase | VGNC:8731 | 460376 | |||||
Macaque | acylaminoacyl-peptide hydrolase | 705948 | ||||||
Mouse | MGI:88041 | 235606 | ||||||
Rat | RGD:2125 | 24206 | ||||||
Dog | acylaminoacyl-peptide hydrolase | VGNC:37982 | 476622 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | acylaminoacyl-peptide hydrolase | |||||
Macaque | acylaminoacyl-peptide hydrolase | |||||
Mouse | ||||||
Rat | ||||||
Dog | acylaminoacyl-peptide hydrolase | |||||
Publication Statistics
PubMed Score 1191.23
PubMed score by year
PubTator Score 222.68
PubTator score by year
Related Publications
Text Mined References (30)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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