Tbio PLS3 Plastin-3

Protein Summary

Description

Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development. Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• P13797
• A8K579
• B1AQ09
• B4DGB4
• B7Z6M1
• Q86YI6

Gene Name

• PLS3

Ensembl ID

• ENST00000289290
• ENSP00000289290
• ENSG00000102024
• ENST00000355899
• ENSP00000348163
• ENST00000539310
• ENSP00000445339

Symbol

• BMND18
• T-plastin

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.98
kinase perturbation	0.93
PubMedID	0.9
disease perturbation	0.87
transcription factor	0.77

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Plastin-3

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Plastin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 331.94   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 213   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 331.94   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0