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Tbio
PLS3
Plastin-3

Protein Summary
Description
Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development. Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289290
  • ENSP00000289290
  • ENSG00000102024
  • ENST00000355899
  • ENSP00000348163
  • ENST00000539310
  • ENSP00000445339

Symbol
  • BMND18
  • T-plastin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
kinase perturbation
0.93
PubMedID
0.9
disease perturbation
0.87
transcription factor
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.6   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.6   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
42.8
platelet count
1
1
1
21
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
42.8
platelet count
1
21
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
plastin 3
VGNC:3832
465817
Macaque
plastin 3
709055
Mouse
MGI:104807
102866
Rat
RGD:621409
81748
Dog
plastin 3
VGNC:44712
481025
Species
Name
OMA
EggNOG
Inparanoid
Chimp
plastin 3
Macaque
plastin 3
Mouse
Rat
Dog
plastin 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P13797-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (122)
1 – 10 of 122
PLS1
Tbio
Novelty: 0.00538817
p_int: 0.99999996
p_ni: 3.5e-8
p_wrong: 5e-9
Score: 0.809
Data Source: BioPlex,STRINGDB
LCP1
Tbio
Novelty: 0.0035357
p_int: 0.999997033
p_ni: 0.000002967
Score: 0.845
Data Source: BioPlex,STRINGDB
KLHL23
Tdark
Novelty: 0.64141058
p_int: 0.996738099
p_ni: 0.003261451
p_wrong: 4.49e-7
Score: 0.232
Data Source: BioPlex,STRINGDB
EZR
Tbio
Novelty: 0.00115353
Score: 0.873
Data Source: STRINGDB
SMN1
Tbio
Family: Epigenetic
Novelty: 0.0008085
Score: 0.864
Data Source: STRINGDB
MSN
Tbio
Novelty: 0.00178275
Score: 0.849
Data Source: STRINGDB
ENO2
Tbio
Family: Enzyme
Novelty: 0.00016748
Score: 0.812
Data Source: STRINGDB
PFN2
Tbio
Novelty: 0.00605366
Score: 0.744
Data Source: STRINGDB
RDX
Tbio
Novelty: 0.00236103
Score: 0.741
Data Source: STRINGDB
FSCN1
Tbio
Novelty: 0.00221877
Score: 0.695
Data Source: STRINGDB
Publication Statistics
PubMed Score  158.60

PubMed score by year
PubTator Score  68.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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