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Tbio
HLA-DOB
HLA class II histocompatibility antigen, DO beta chain

Protein Summary
Description
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000426644
  • ENSP00000395780
  • ENSG00000243612
  • ENST00000438763
  • ENSP00000390020
  • ENSG00000241106
  • ENST00000447178
  • ENSP00000405108
  • ENSG00000241386
  • ENST00000454286
  • ENSP00000397268
  • ENSG00000243496
  • ENST00000454969
  • ENSP00000410390
  • ENSG00000241910
  • ENST00000456406
  • ENSP00000394783
  • ENSG00000239457
  • ENST00000648009
  • ENSP00000496848

Symbol
  • DOB
  • HLA_DOB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cellular component
0.82
phenotype
0.68
tissue sample
0.68
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.58   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.58   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (36)
Items per page:
1 – 5 of 36
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
0
1.3
82.5
smoking status measurement
2
2
0
1.3
82.5
smoking status measurement
2
2
0
1.3
82.5
smoking status measurement
2
2
0
1.3
82.5
smoking status measurement
2
2
0
1.3
82.5
Items per page:
1 – 5 of 36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
0
1.3
82.5
smoking status measurement
0
1.3
82.5
smoking status measurement
0
1.3
82.5
smoking status measurement
0
1.3
82.5
smoking status measurement
0
1.3
82.5
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95925
15002
Rat
RGD:1595814
365542
Dog
major histocompatibility complex, class II, DO beta
607786
Cow
major histocompatibility complex, class II, DO beta
282493
Pig
MHC class II, DO beta
100135049
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
major histocompatibility complex, class II, DO beta
Cow
major histocompatibility complex, class II, DO beta
Pig
MHC class II, DO beta
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P13765-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
MHC class II antigen presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
MHC class II antigen presentation
Protein-Protein Interactions (174)
1 – 10 of 174
HLA-DMA
Tbio
Novelty: 0.00405566
Score: 0.995
Data Source: Reactome,STRINGDB
HLA-DOA
Tbio
Novelty: 0.01222732
Score: 0.99
Data Source: Reactome,STRINGDB
HLA-DMB
Tbio
Novelty: 0.02289537
Score: 0.959
Data Source: Reactome,STRINGDB
HLA-DRA
Tbio
Novelty: 0.0060214
Score: 0.934
Data Source: Reactome,STRINGDB
CD74
Tchem
Novelty: 0.00281228
Score: 0.934
Data Source: Reactome,STRINGDB
HLA-DPA1
Tbio
Novelty: 0.01080446
Score: 0.93
Data Source: Reactome,STRINGDB
HLA-DQA2
Tbio
Novelty: 0.00431613
Score: 0.928
Data Source: Reactome,STRINGDB
HLA-B
Tbio
Novelty: 0.00790207
Score: 0.925
Data Source: STRINGDB
HLA-B
Tbio
Novelty: 0.00790207
Score: 0.925
Data Source: STRINGDB
HLA-B
Tbio
Novelty: 0.00790207
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.58

PubMed score by year
PubTator Score  44.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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