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Tbio
HLA-DOB
HLA class II histocompatibility antigen, DO beta chain

Protein Summary
Description
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000426644
  • ENSP00000395780
  • ENSG00000243612
  • ENST00000438763
  • ENSP00000390020
  • ENSG00000241106
  • ENST00000447178
  • ENSP00000405108
  • ENSG00000241386
  • ENST00000454286
  • ENSP00000397268
  • ENSG00000243496
  • ENST00000454969
  • ENSP00000410390
  • ENSG00000241910
  • ENST00000456406
  • ENSP00000394783
  • ENSG00000239457
  • ENST00000648009
  • ENSP00000496848

Symbol
  • DOB
  • HLA_DOB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cellular component
0.82
phenotype
0.68
tissue sample
0.68
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.13   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.13   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0