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Tbio
P13761
HLA class II histocompatibility antigen, DRB1-7 beta chain

Protein Summary
Description
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000437784
  • ENSP00000405960
  • ENSG00000229074
  • ENST00000444645
  • ENSP00000409322
  • ENSG00000236884

Symbol
  • SS1
  • DRB1
  • HLA-DRB
  • HLA-DR1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4250.46   (req: < 5)
Gene RIFs: 1105   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4250.46   (req: >= 5)
Gene RIFs: 1105   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (390)
HLA-DRB3
Tchem
p_int:  0.999999995
p_ni:  4e-9
Data Source:  BioPlex
P01911
Tchem
Novelty:  0.00240724
p_int:  0.999995348
p_ni:  0.000003381
p_wrong:  0.000001272
Data Source:  BioPlex
HLA-DRA
Tbio
Novelty:  0.0060214
Score:  0.999
Data Source:  STRINGDB
CD74
Tchem
Novelty:  0.00281228
Score:  0.998
Data Source:  STRINGDB
HLA-DMA
Tbio
Novelty:  0.00405566
Score:  0.997
Data Source:  STRINGDB
CD4
Tclin
Novelty:  0.00001217
Score:  0.986
Data Source:  STRINGDB
PTPN22
Tchem
Family:  Enzyme
Novelty:  0.00168847
Score:  0.98
Data Source:  STRINGDB
HLA-DRB5
Tbio
Novelty:  0.00291303
Score:  0.98
Data Source:  STRINGDB
HLA-DMB
Tbio
Novelty:  0.02289537
Score:  0.979
Data Source:  STRINGDB
HLA-DPA1
Tbio
Novelty:  0.01080446
Score:  0.975
Data Source:  STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
1 – 2 of 2
JAK2
Tclin
Family:  Kinase
KEGG Distance:  4
Common Pathways:  7
more:  3 more common pathways
Pathways (95)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream TCR signaling
Reactome
Generation of second messenger molecules
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Cytokine Signaling in Immune system
Downstream TCR signaling
Generation of second messenger molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1404)
Items per page:
1 – 5 of 1404
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
15
13
18
2.2
99.8
15
13
6
2.2
99.8
15
13
12
2.2
99.8
15
13
18
2.2
99.8
15
13
6
2.2
99.8
Items per page:
1 – 5 of 1404
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
18
2.2
99.8
6
2.2
99.8
12
2.2
99.8
18
2.2
99.8
6
2.2
99.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 4250.46
PubMed score by year
PubTator Score 4503.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title