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Tbio
HLA-E
HLA class I histocompatibility antigen, alpha chain E

Protein Summary
Description
Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (VL9 peptides) (PubMed:9754572, PubMed:18083576, PubMed:18339401). Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, enabling NK cells to monitor the expression of other MHC class I molecules in healthy cells and to tolerate self (PubMed:9754572, PubMed:9486650, PubMed:17179229, PubMed:18083576). Upon cellular stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1-KLRC1, resulting in impaired protection from NK cells (PubMed:12461076). Binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules and acts as a ligand for NK cell act ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383597
  • ENSP00000373091
  • ENSG00000206493
  • ENST00000415289
  • ENSP00000409910
  • ENSG00000229252
  • ENST00000415649
  • ENSP00000390707
  • ENSG00000233904
  • ENST00000427936
  • ENSP00000397420
  • ENSG00000230254

Symbol
  • HLA-6.2
  • HLAE
  • QA1
  • HLA-6.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.97
biological process
0.96
biological term
0.88
disease
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 547.05   (req: < 5)
Gene RIFs: 149   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 547.05   (req: >= 5)
Gene RIFs: 149   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
46.3
platelet crit
1
1
1
46.3
platelet crit
1
1
1
46.3
platelet crit
1
1
1
46.3
Oral ulcer
1
1
0
1
8.4
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
46.3
platelet crit
1
46.3
platelet crit
1
46.3
platelet crit
1
46.3
Oral ulcer
0
1
8.4
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
patr class I histocompatibility antigen, A-126 alpha chain
750725
Species
Name
OMA
EggNOG
Inparanoid
Chimp
patr class I histocompatibility antigen, A-126 alpha chain
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P13747-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (77)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Gene Ontology Terms (42)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (327)
1 – 10 of 327
HLA-B
Tbio
Novelty: 0.00790207
p_int: 0.999999626
p_ni: 3.74e-7
Score: 0.966
Data Source: BioPlex,STRINGDB
ECEL1
Tbio
Family: Enzyme
Novelty: 0.01488521
p_int: 0.999670812
p_ni: 0.000329187
p_wrong: 1e-9
Data Source: BioPlex
HLA-A
Tbio
Novelty: 0.00270731
p_int: 0.999658149
p_ni: 0.000341851
Score: 0.936
Data Source: BioPlex,STRINGDB
CNTNAP3
Tdark
Novelty: 0.22791524
p_int: 0.998866598
p_ni: 0.001133402
Data Source: BioPlex
HLA-C
Tbio
Novelty: 0.00698601
p_int: 0.99533142
p_ni: 0.00466858
Score: 0.967
Data Source: BioPlex,STRINGDB
FCGRT
Tchem
Novelty: 0.00105713
p_int: 0.99140209
p_ni: 0.00859791
Score: 0.461
Data Source: BioPlex,STRINGDB
HLA-G
Tbio
Novelty: 0.0009462
p_int: 0.988282919
p_ni: 0.011717081
Score: 0.969
Data Source: BioPlex,STRINGDB
ITGA6
Tbio
Novelty: 0.00217985
p_int: 0.986269973
p_ni: 0.013730027
p_wrong: 1e-9
Data Source: BioPlex
ASPH
Tbio
Family: Enzyme
Novelty: 0.00291455
p_int: 0.976505747
p_ni: 0.023494253
Data Source: BioPlex
EPHB4
Tchem
Family: Kinase
Novelty: 0.00422975
p_int: 0.975819259
p_ni: 0.024180739
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  547.05

PubMed score by year
PubTator Score  356.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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