Tbio PRG2 Bone marrow proteoglycan

Protein Summary

Description

Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• P13727
• A6XMW0
• B2R5I1
• P81448
• Q14227
• Q6ICT2
• BMPG

Gene Name

• PRG2

Ensembl ID

• ENST00000311862
• ENSP00000312134
• ENSG00000186652
• ENST00000525955
• ENSP00000433016
• ENST00000533605
• ENSP00000433231

Symbol

• MBP
• MBP
• BMPG
• MBP1
• proMBP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.75
protein domain	0.73
cell type or tissue	0.65
kinase perturbation	0.6
biological term	0.5

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Extracellular Matrix Structural Protein / Bone Marrow Proteoglycan

Protein / Defense/immunity Protein / Antibacterial Response Protein / Bone Marrow Proteoglycan

Protein / ... / Protease Inhibitor / Bone Marrow Proteoglycan

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Bone Marrow Proteoglycan

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.72   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 264   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 180.72   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0