Tclin F3 Tissue factor

Protein Summary

Description

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Uniprot Accession IDs

• P13726
• D3DT47
• Q6FHG2
• Q86WH4
• TF

Gene Name

• F3

Ensembl ID

• ENST00000334047
• ENSP00000334145
• ENSG00000117525
• ENST00000370207
• ENSP00000359226

Symbol

• TF
• TFA
• CD142

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.99
small molecule perturbation	0.94
chemical	0.89
biological process	0.82
biological term	0.76

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Tissue Factor

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Tissue Factor

Protein / Defense/immunity Protein / Tissue Factor

DTO Classes

Protein / Receptor / Cytokine Receptor / Type Ii Cytokine Receptor / Tissue Factor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16988.98   (req: < 5)

Gene RIFs: 572   (req: <= 3)

Antibodies: 863   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16988.98   (req: >= 5)

Gene RIFs: 572   (req: > 3)

Antibodies: 863   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 131

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1