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Tbio
OSM
Oncostatin-M

Protein Summary
Description
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215781
  • ENSP00000215781
  • ENSG00000099985
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
biological term
0.84
virus perturbation
0.68
PubMedID
0.62
tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 521.75   (req: < 5)
Gene RIFs: 115   (req: <= 3)
Antibodies: 577   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 521.75   (req: >= 5)
Gene RIFs: 115   (req: > 3)
Antibodies: 577   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
1
1
27.3
heel bone mineral density
2
1
2
25.3
reticulocyte measurement
2
1
2
24.1
1
1
1
2.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
1
27.3
heel bone mineral density
2
25.3
reticulocyte measurement
2
24.1
1
2.7
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (258)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
IL-6-type cytokine receptor ligand interactions
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Interleukin-6 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
IL-6-type cytokine receptor ligand interactions
Immune System
Interleukin-4 and Interleukin-13 signaling
Interleukin-6 family signaling
Gene Ontology Terms (25)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (165)
1 – 10 of 165
IL6ST
Tclin
Novelty: 0.01026472
p_int: 0.999999776
p_ni: 2.2e-7
p_wrong: 4e-9
Score: 0.985
Data Source: BioPlex,Reactome,STRINGDB
C5orf22
Tdark
Novelty: 1.29325352
p_int: 0.99993194
p_ni: 0.000040495
p_wrong: 0.000027566
Score: 0.534
Data Source: BioPlex,STRINGDB
C1QBP
Tbio
Novelty: 0.00532825
p_int: 0.998342809
p_ni: 0.001657191
Score: 0.185
Data Source: BioPlex,STRINGDB
TRPM3
Tchem
Family: IC
Novelty: 0.00647452
p_int: 0.982380746
p_ni: 0.000813087
p_wrong: 0.016806166
Score: 0.534
Data Source: BioPlex,STRINGDB
ZNF579
Tdark
Family: TF
Novelty: 4.75515836
p_int: 0.830784453
p_ni: 0.162884422
p_wrong: 0.006331125
Score: 0.198
Data Source: BioPlex,STRINGDB
OSMR
Tbio
Novelty: 0.01554974
Score: 0.994
Data Source: Reactome,STRINGDB
LIFR
Tbio
Novelty: 0.00514085
Score: 0.982
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.982
Data Source: STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.957
Data Source: Reactome,STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.956
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  521.75

PubMed score by year
PubTator Score  405.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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