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Tbio
ALAD
Delta-aminolevulinic acid dehydratase

Protein Summary
Description
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409155
  • ENSP00000386284
  • ENSG00000148218

Symbol
  • PBGS
  • ALADH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
chemical
0.89
transcription factor binding site profile
0.86
virus perturbation
0.72
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1115.36   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1115.36   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood lead measurement
1
1
1
68.9
reticulocyte measurement
2
1
2
32.6
reticulocyte count
2
1
2
31.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood lead measurement
1
68.9
reticulocyte measurement
2
32.6
reticulocyte count
2
31.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aminolevulinate dehydratase
VGNC:4607
464675
Macaque
aminolevulinate dehydratase
705193
Mouse
MGI:96853
17025
Rat
RGD:2083
25374
Dog
aminolevulinate dehydratase
VGNC:37775
474808
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aminolevulinate dehydratase
Macaque
aminolevulinate dehydratase
Mouse
Rat
Dog
aminolevulinate dehydratase
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P13716-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Heme biosynthesis (R-HSA-189451)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Heme biosynthesis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Iron uptake and transport
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Heme biosynthesis
Immune System
Innate Immune System
Iron uptake and transport
Metabolism
Gene Ontology Terms (40)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (117)
1 – 10 of 117
ARHGEF35
Tdark
Novelty: 4.94268866
p_int: 0.999998199
p_ni: 0.000001799
p_wrong: 2e-9
Score: 0.313
Data Source: BioPlex,STRINGDB
ISOC2
Tbio
Family: Enzyme
Novelty: 0.33841868
p_int: 0.999978163
p_ni: 0.00002183
p_wrong: 8e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
GMFB
Tbio
Novelty: 0.01531815
p_int: 0.999754943
p_ni: 0.000090694
p_wrong: 0.000154363
Data Source: BioPlex
ANKRD22
Tdark
Novelty: 0.28856283
p_int: 0.999409682
p_ni: 0.000177236
p_wrong: 0.000413083
Data Source: BioPlex
CCDC103
Tbio
Novelty: 0.07857649
p_int: 0.966121907
p_ni: 0.000400443
p_wrong: 0.03347765
Data Source: BioPlex
PLK2
Tchem
Family: Kinase
Novelty: 0.00750465
p_int: 0.926009379
p_ni: 0.001247069
p_wrong: 0.072743551
Score: 0.188
Data Source: BioPlex,STRINGDB
CNN2
Tbio
Novelty: 0.02486182
p_int: 0.886005505
p_ni: 0.000083713
p_wrong: 0.113910782
Score: 0.356
Data Source: BioPlex,STRINGDB
HMBS
Tbio
Family: Enzyme
Novelty: 0.00193847
Score: 0.997
Data Source: STRINGDB
ALAS2
Tbio
Family: Enzyme
Novelty: 0.00491418
Score: 0.979
Data Source: STRINGDB
UROS
Tbio
Family: Enzyme
Novelty: 0.00938683
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  1115.36

PubMed score by year
PubTator Score  732.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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