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Tbio
TPT1
Translationally-controlled tumor protein

Protein Summary
Description
Involved in calcium binding and microtubule stabilization. This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379055
  • ENSP00000368344
  • ENSG00000133112
  • ENST00000379056
  • ENSP00000368345
  • ENST00000530705
  • ENSP00000431872

Symbol
  • HRF
  • p02
  • p23
  • TCTP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
transcription factor binding site profile
0.94
virus perturbation
0.94
transcription factor
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 547.68   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 501   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 547.68   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 501   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (200)
LACC1
Tbio
Family:  Enzyme
Novelty:  0.03928871
p_int:  0.9995299
p_ni:  0.0004701
Data Source:  BioPlex
CST7
Tbio
Novelty:  0.03651959
p_int:  0.972608393
p_ni:  0.027380428
p_wrong:  0.000011178
Score:  0.309
Data Source:  BioPlex,STRINGDB
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.921417347
p_ni:  0.078582653
Score:  0.631
Data Source:  BioPlex,STRINGDB
BCL2L1
Tchem
Novelty:  0.00018414
Score:  0.989
Data Source:  STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
Score:  0.982
Data Source:  STRINGDB
RPS25
Tbio
Novelty:  0.02812798
Score:  0.981
Data Source:  STRINGDB
RPL27
Tbio
Novelty:  0.0157566
Score:  0.98
Data Source:  STRINGDB
STEAP3
Tbio
Family:  Enzyme
Novelty:  0.02042104
Score:  0.974
Data Source:  STRINGDB
EEF1B2
Tbio
Novelty:  0.00970356
Score:  0.973
Data Source:  STRINGDB
RPS3A
Tbio
Novelty:  0.01009445
Score:  0.973
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
1
2
67.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
2
67.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translationally-controlled tumor protein
735922
Macaque
tumor protein, translationally-controlled 1
702155
Mouse
MGI:104890
22070
Rat
RGD:621623
116646
Dog
tumor protein, translationally-controlled 1
476924
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translationally-controlled tumor protein
Macaque
tumor protein, translationally-controlled 1
Mouse
Rat
Dog
tumor protein, translationally-controlled 1
Publication Statistics
PubMed Score 547.68
PubMed score by year
PubTator Score 411.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title