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Tbio
CEACAM1
Carcinoembryonic antigen-related cell adhesion molecule 1

Protein Summary
Description
Isoform 1: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000161559
  • ENSP00000161559
  • ENSG00000079385
  • ENST00000352591
  • ENSP00000244291
  • ENST00000358394
  • ENSP00000351165
  • ENST00000403444
  • ENSP00000384709
  • ENST00000403461
  • ENSP00000384083
  • ENST00000599389
  • ENSP00000471918

Symbol
  • BGP
  • BGP1
  • BGP
  • BGP1
  • BGPI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
1
PubMedID
0.99
biological term
0.93
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 381.66   (req: < 5)
Gene RIFs: 189   (req: <= 3)
Antibodies: 828   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 381.66   (req: >= 5)
Gene RIFs: 189   (req: > 3)
Antibodies: 828   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Extracellular matrix organization
Reactome
Fibronectin matrix formation
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Extracellular matrix organization
Fibronectin matrix formation
Hemostasis
Immune System
Gene Ontology Terms (65)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (163)
1 – 10 of 163
CEACAM3
Tbio
Novelty: 0.03544819
Score: 0.943
Data Source: STRINGDB
CD300A
Tbio
Novelty: 0.01807591
Score: 0.941
Data Source: STRINGDB
HVCN1
Tchem
Family: IC
Novelty: 0.00192429
Score: 0.94
Data Source: STRINGDB
CEACAM8
Tbio
Novelty: 0.00515482
Score: 0.937
Data Source: Reactome,STRINGDB
CD177
Tbio
Novelty: 0.00305746
Score: 0.933
Data Source: STRINGDB
LAIR1
Tbio
Novelty: 0.01625383
Score: 0.929
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.0000437
Score: 0.927
Data Source: STRINGDB
PTAFR
Tchem
Family: GPCR
Novelty: 0.00890235
Score: 0.925
Data Source: STRINGDB
ITGAM
Tbio
Novelty: 0.0002405
Score: 0.921
Data Source: STRINGDB
MS4A3
Tbio
Novelty: 0.06998834
Score: 0.919
Data Source: STRINGDB
Publication Statistics
PubMed Score  381.66

PubMed score by year
PubTator Score  365.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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