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Tbio
ACP5
Tartrate-resistant acid phosphatase type 5

Protein Summary
Description
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias. This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218758
  • ENSP00000218758
  • ENSG00000102575
  • ENST00000412435
  • ENSP00000392374
  • ENST00000433365
  • ENSP00000413456
  • ENST00000592828
  • ENSP00000468767
  • ENST00000648477
  • ENSP00000496973

Symbol
  • HPAP
  • TRAP
  • TRACP5a
  • TRACP5b
  • TrATPase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.8
transcription factor
0.76
biological process
0.72
biological term
0.63
chemical
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2394.51   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 534   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2394.51   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 534   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (354)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamin B2 (riboflavin) metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamin B2 (riboflavin) metabolism
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (111)
1 – 10 of 111
HSD17B7
Tchem
Family: Enzyme
Novelty: 0.04295724
p_int: 0.996037303
p_ni: 0.003961562
p_wrong: 0.000001136
Score: 0.54
Data Source: BioPlex,STRINGDB
CIZ1
Tbio
Novelty: 0.03730538
p_int: 0.993360611
p_ni: 0.006639389
Score: 0.325
Data Source: BioPlex,STRINGDB
KLHL15
Tbio
Novelty: 0.54712519
p_int: 0.811029879
p_ni: 0.188970121
Score: 0.205
Data Source: BioPlex,STRINGDB
ENPP1
Tchem
Family: Enzyme
Novelty: 0.00256132
Score: 0.929
Data Source: STRINGDB
CTSK
Tchem
Family: Enzyme
Novelty: 0.0007707
Score: 0.928
Data Source: STRINGDB
TNFSF11
Tclin
Novelty: 0.00018328
Score: 0.922
Data Source: STRINGDB
ENPP3
Tbio
Family: Enzyme
Novelty: 0.00414129
Score: 0.912
Data Source: STRINGDB
BLVRB
Tbio
Family: Enzyme
Novelty: 0.00705559
Score: 0.904
Data Source: STRINGDB
FLAD1
Tbio
Family: Enzyme
Novelty: 0.02230368
Score: 0.903
Data Source: STRINGDB
ACP2
Tbio
Family: Enzyme
Novelty: 0.00355652
Score: 0.887
Data Source: STRINGDB
Publication Statistics
PubMed Score  2394.51

PubMed score by year
PubTator Score  223.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer