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Tchem
P4HA1
Prolyl 4-hydroxylase subunit alpha-1

Protein Summary
Description
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263556
  • ENSP00000263556
  • ENSG00000122884
  • ENST00000307116
  • ENSP00000307318
  • ENST00000373008
  • ENSP00000362099
  • ENST00000394890
  • ENSP00000378353
  • ENST00000440381
  • ENSP00000414464

Symbol
  • P4HA
  • P4HA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.9
molecular function
0.88
protein domain
0.85
transcription factor binding site profile
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.47   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.47   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen formation
Extracellular matrix organization
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (148)
1 – 10 of 148
WDR33
Tbio
Novelty: 0.09221439
p_int: 0.999999953
p_ni: 4.7e-8
Score: 0.231
Data Source: BioPlex,STRINGDB
CPSF4
Tbio
Novelty: 0.00206207
p_int: 0.999999891
p_ni: 1.09e-7
p_wrong: 1e-9
Score: 0.33
Data Source: BioPlex,STRINGDB
L3MBTL3
Tchem
Family: Epigenetic
Novelty: 0.04659049
p_int: 0.999999004
p_ni: 9.95e-7
Score: 0.163
Data Source: BioPlex,STRINGDB
ZNF628
Tdark
Family: TF
Novelty: 0.50407457
p_int: 0.999996723
p_ni: 0.000002762
p_wrong: 5.16e-7
Data Source: BioPlex
ZNF397
Tbio
Family: TF
Novelty: 0.60034816
p_int: 0.999988933
p_ni: 0.000011066
p_wrong: 1e-9
Data Source: BioPlex
COL2A1
Tbio
Novelty: 0.0011102
p_int: 0.99998342
p_ni: 0.000016579
p_wrong: 1e-9
Score: 0.924
Data Source: BioPlex,STRINGDB
RNPC3
Tbio
Novelty: 0.07154673
p_int: 0.999983219
p_ni: 0.000016781
Data Source: BioPlex
KSR1
Tbio
Family: Kinase
Novelty: 0.00691155
p_int: 0.999982188
p_ni: 0.000017812
Data Source: BioPlex
SYMPK
Tbio
Novelty: 0.01773552
p_int: 0.999938519
p_ni: 0.000061475
p_wrong: 6e-9
Data Source: BioPlex
YLPM1
Tdark
Novelty: 0.26435727
p_int: 0.999925592
p_ni: 0.000074408
Data Source: BioPlex
Publication Statistics
PubMed Score  65.47

PubMed score by year
PubTator Score  18.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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