Tchem P4HA1 Prolyl 4-hydroxylase subunit alpha-1

Protein Summary

Description

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P13674
• C9JL12
• Q15082
• Q15083
• Q5VSQ5
• 4-PH alpha-1

Gene Name

• P4HA1

Ensembl ID

• ENST00000263556
• ENSP00000263556
• ENSG00000122884
• ENST00000307116
• ENSP00000307318
• ENST00000373008
• ENSP00000362099
• ENST00000394890
• ENSP00000378353
• ENST00000440381
• ENSP00000414464

Symbol

• P4HA
• P4HA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
disease perturbation	0.9
molecular function	0.88
protein domain	0.85
transcription factor binding site profile	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.3   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 236   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.3   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0