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Tbio
C6
Complement component C6

Protein Summary
Description
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263413
  • ENSP00000263413
  • ENSG00000039537
  • ENST00000337836
  • ENSP00000338861
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
co-expressed gene
0.65
cell line
0.61
tissue sample
0.6
gene perturbation
0.57


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.33   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.33   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C6
VGNC:3923
449612
Macaque
complement C6
696266
Mouse
MGI:88233
12274
Rat
RGD:2238
24237
Dog
complement C6
VGNC:38598
479348
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C6
Macaque
complement C6
Mouse
Rat
Dog
complement C6
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P13671-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of Complement cascade
Reactome
Terminal pathway of complement
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Regulation of Complement cascade
Terminal pathway of complement
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (84)
1 – 10 of 84
DPY19L3
Tbio
Family: Enzyme
Novelty: 0.35244121
p_int: 0.999965824
p_ni: 0.000034167
p_wrong: 9e-9
Score: 0.29
Data Source: BioPlex,STRINGDB
ACOT9
Tbio
Family: Enzyme
Novelty: 0.17405187
p_int: 0.998416862
p_ni: 0.001583138
Score: 0.25
Data Source: BioPlex,STRINGDB
B3GLCT
Tbio
Family: Enzyme
Novelty: 0.02398944
p_int: 0.78194519
p_ni: 0.21805481
Score: 0.309
Data Source: BioPlex,STRINGDB
C5
Tclin
Novelty: 0.00225386
Score: 0.993
Data Source: Reactome,STRINGDB
C8A
Tbio
Novelty: 0.00429321
Score: 0.957
Data Source: Reactome,STRINGDB
C8B
Tbio
Novelty: 0.00873524
Score: 0.935
Data Source: Reactome,STRINGDB
C8G
Tbio
Novelty: 0.02322575
Score: 0.929
Data Source: Reactome,STRINGDB
C9
Tbio
Novelty: 0.00749298
Score: 0.928
Data Source: Reactome,STRINGDB
C7
Tbio
Novelty: 0.01540501
Score: 0.924
Data Source: Reactome,STRINGDB
VTN
Tbio
Family: TF
Novelty: 0.00046861
Score: 0.921
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  71.33

PubMed score by year
PubTator Score  1498.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer