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Tbio
PDIA4
Protein disulfide-isomerase A4

Protein Summary
Description
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286091
  • ENSP00000286091
  • ENSG00000155660

Symbol
  • ERP70
  • ERP72
  • ERP70
  • ERP72
  • ERp-72
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
protein domain
0.85
kinase perturbation
0.84
transcription factor perturbation
0.84
transcription factor binding site profile
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.72   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 387   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.72   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
EMC3
Tbio
Novelty:  0.01113829
p_int:  0.967134712
p_ni:  0.032865288
Score:  0.84
Data Source:  BioPlex,STRINGDB
EMC7
Tdark
Novelty:  0.28771768
p_int:  0.922800834
p_ni:  0.077199166
Score:  0.828
Data Source:  BioPlex,STRINGDB
HYOU1
Tbio
Novelty:  0.00833649
Score:  0.993
Data Source:  STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
Score:  0.991
Data Source:  STRINGDB
HSP90B1
Tchem
Novelty:  0.00135881
Score:  0.991
Data Source:  STRINGDB
CALR
Tbio
Novelty:  0.0004479
Score:  0.976
Data Source:  STRINGDB
ERO1A
Tbio
Novelty:  0.01022914
Score:  0.956
Data Source:  STRINGDB
MANF
Tbio
Novelty:  0.00586461
Score:  0.955
Data Source:  STRINGDB
DNAJC3
Tbio
Novelty:  0.02129782
Score:  0.95
Data Source:  STRINGDB
PDIA6
Tchem
Family:  Enzyme
Novelty:  0.01692178
Score:  0.91
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Vibrio cholerae infection
KEGG
Protein processing in endoplasmic reticulum
KEGG
Thyroid hormone synthesis
Name
Explore in Pharos
Explore in Source
Vibrio cholerae infection
Protein processing in endoplasmic reticulum
Thyroid hormone synthesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
6
7
87
body height
3
3
3
82.1
BMI-adjusted waist circumference
3
6
7
81.1
neutrophil count
1
1
1
44.2
sum of basophil and neutrophil counts
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
7
87
body height
3
82.1
BMI-adjusted waist circumference
7
81.1
neutrophil count
1
44.2
sum of basophil and neutrophil counts
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein disulfide isomerase family A member 4
VGNC:4462
463822
Mouse
MGI:104864
12304
Rat
RGD:619835
116598
Dog
protein disulfide isomerase family A member 4
VGNC:44377
482715
Horse
protein disulfide isomerase family A member 4 [Source:HGNC Symbol;Acc:HGNC:30167]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein disulfide isomerase family A member 4
Mouse
Rat
Dog
protein disulfide isomerase family A member 4
Horse
protein disulfide isomerase family A member 4 [Source:HGNC Symbol;Acc:HGNC:30167]
Publication Statistics
PubMed Score 67.72
PubMed score by year
PubTator Score 31.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title