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Tbio
KRT5
Keratin, type II cytoskeletal 5

Protein Summary
Description
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252242
  • ENSP00000252242
  • ENSG00000186081

Symbol
  • K5
  • CK5
  • DDD
  • DDD1
  • EBS2
  • KRT5A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
gene perturbation
0.84
cellular component
0.81
biological term
0.77
hub protein
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 749.95   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 1316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 749.95   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 1316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Protein-Protein Interactions (186)
1 – 10 of 186
KRT14
Tbio
Novelty: 0.0012542
Score: 0.999
Data Source: STRINGDB
KRT1
Tbio
Novelty: 0.00344378
Score: 0.997
Data Source: STRINGDB
KRT16
Tbio
Novelty: 0.00602741
Score: 0.996
Data Source: STRINGDB
KRT2
Tbio
Novelty: 0.02059971
Score: 0.996
Data Source: STRINGDB
KRT10
Tbio
Novelty: 0.00148059
Score: 0.995
Data Source: STRINGDB
KRT3
Tbio
Novelty: 0.00669689
Score: 0.993
Data Source: STRINGDB
KRT17
Tbio
Novelty: 0.0038148
Score: 0.968
Data Source: STRINGDB
KRT6B
Tbio
Novelty: 0.00713479
Score: 0.966
Data Source: STRINGDB
KRT6A
Tbio
Novelty: 0.01158599
Score: 0.962
Data Source: STRINGDB
KRT18
Tbio
Novelty: 0.00086008
Score: 0.962
Data Source: STRINGDB
Publication Statistics
PubMed Score  749.95

PubMed score by year
PubTator Score  891.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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