Tbio KRT5 Keratin, type II cytoskeletal 5

Protein Summary

Description

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P13647
• Q6PI71
• Q6UBJ0
• Q8TA91

Gene Name

• KRT5

Ensembl ID

• ENST00000252242
• ENSP00000252242
• ENSG00000186081

Symbol

• K5
• CK5
• DDD
• DDD1
• EBS2
• KRT5A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
gene perturbation	0.84
cellular component	0.81
biological term	0.77
hub protein	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1569.63   (req: < 5)

Gene RIFs: 133   (req: <= 3)

Antibodies: 1316   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1569.63   (req: >= 5)

Gene RIFs: 133   (req: > 3)

Antibodies: 1316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0