Tbio KRT5 Keratin, type II cytoskeletal 5

Protein Summary

Description

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P13647
• Q6PI71
• Q6UBJ0
• Q8TA91

Gene Name

• KRT5

Ensembl ID

• ENST00000252242
• ENSP00000252242
• ENSG00000186081

Symbol

• K5
• CK5
• DDD
• DDD1
• EBS2
• KRT5A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
gene perturbation	0.84
cellular component	0.81
biological term	0.77
hub protein	0.71

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 749.95   (req: < 5)

Gene RIFs: 106   (req: <= 3)

Antibodies: 1316   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 749.95   (req: >= 5)

Gene RIFs: 106   (req: > 3)

Antibodies: 1316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (5)

Reactome (2)

PathwayCommons (3)

Developmental Biology (R-HSA-1266738)

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Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Keratinization	217 targets	R-HSA-6805567

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Keratinization	217 targets	R-HSA-6805567

Gene Ontology Terms (14)

Functions (2)

Components (8)

Processes (4)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
scaffold protein binding	Inferred from Physical Interaction (IPI)	BHF-UCL
structural constituent of cytoskeleton	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (186)

Explore Interacting Targets

1 – 10 of 186

• See Interactions on String-DB

KRT14

Tbio

Novelty: 0.0012542

Score: 0.999

Data Source: STRINGDB

KRT1

Tbio

Novelty: 0.00344378

Score: 0.997

Data Source: STRINGDB

KRT16

Tbio

Novelty: 0.00602741

Score: 0.996

Data Source: STRINGDB

KRT2

Tbio

Novelty: 0.02059971

Score: 0.996

Data Source: STRINGDB

KRT10

Tbio

Novelty: 0.00148059

Score: 0.995

Data Source: STRINGDB

KRT3

Tbio

Novelty: 0.00669689

Score: 0.993

Data Source: STRINGDB

KRT17

Tbio

Novelty: 0.0038148

Score: 0.968

Data Source: STRINGDB

KRT6B

Tbio

Novelty: 0.00713479

Score: 0.966

Data Source: STRINGDB

KRT6A

Tbio

Novelty: 0.01158599

Score: 0.962

Data Source: STRINGDB

KRT18

Tbio

Novelty: 0.00086008

Score: 0.962

Data Source: STRINGDB

Publication Statistics

PubMed Score  749.95

PubMed score by year

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PubTator Score  891.87

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MSRQSSVSFRSGGSRSFSTASAITPSVSRTSFTSVSRSGGGGGGGFGRVSLAGACGVGGYGSRSLYNLGG

1-70

SKRISISTSGGSFRNRFGAGAGGGYGFGGGAGSGFGFGGGAGGGFGLGGGAGFGGGFGGPGFPVCPPGGI

70-140

QEVTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKT

140-210

VRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEINKRTTAENEFVMLKKDVD

210-280

AAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIA

280-350

NRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAEQR

350-420

GELALKDARNKLAELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVN

420-490

ISVVTSSVSSGYGSGSGYGGGLGGGLGGGLGGGLAGGSSGSYYSSSSGGVGLGGGLSVGGSGFSASSGRG

490-560

LGVGFGSGGGSSSSVKFVSTTSSSRKSFKS

560-590

MSRQSSVSFRSGGSRSFSTASAITPSVSRTSFTSVSRSGGGGGGGFGRVSLAGACGVGGYGSRSLYNLGGSKRISISTSGGSFRNRFGAGAGGGYGFGGGAGSGFGFGGGAGGGFGLGGGAGFGGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAEQRGELALKDARNKLAELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTSSVSSGYGSGSGYGGGLGGGLGGGLGGGLAGGSSGSYYSSSSGGVGLGGGLSVGGSGFSASSGRGLGVGFGSGGGSSSSVKFVSTTSSSRKSFKS

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Uniprot Keyword

3D-structure
Coiled coil
Complete proteome
Disease mutation
Epidermolysis bullosa
Intermediate filament
Keratin
Phosphoprotein
Polymorphism
Reference proteome