KRT5
Keratin, type II cytoskeletal 5
Protein Summary
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
- ENST00000252242
- ENSP00000252242
- ENSG00000186081
- K5
- CK5
- DDD
- DDD1
- EBS2
- KRT5A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
gene perturbation | 0.84 | ||
cellular component | 0.81 | ||
biological term | 0.77 | ||
hub protein | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1286.8 (req: < 5)
Gene RIFs: 106 (req: <= 3)
Antibodies: 1316 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1286.8 (req: >= 5)
Gene RIFs: 106 (req: > 3)
Antibodies: 1316 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (186)
Nearest Tclin Targets
Pathways (5)
Reactome (2)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (2)
Components (8)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
keratinocyte carcinoma | 1 | 2 | 0 | 1.1 | 90.6 | ||||
4 | 1 | 1 | 1.2 | 81.2 | |||||
balding measurement | 1 | 2 | 2 | 72.5 | |||||
non-melanoma skin carcinoma | 1 | 1 | 0 | 1.3 | 54.4 | ||||
plasminogen activator inhibitor 1 measurement | 1 | 1 | 0 | 590.4 | 34.6 | ||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
keratinocyte carcinoma | 0 | 1.1 | 90.6 | ||||
1 | 1.2 | 81.2 | |||||
balding measurement | 2 | 72.5 | |||||
non-melanoma skin carcinoma | 0 | 1.3 | 54.4 | ||||
plasminogen activator inhibitor 1 measurement | 0 | 590.4 | 34.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | keratin 5 | 100424400 | ||||||
Mouse | MGI:96702 | 110308 | ||||||
Rat | RGD:727894 | 369017 | ||||||
Horse | keratin 5 | VGNC:19535 | 100061626 | |||||
Cow | keratin 5 | VGNC:50405 | 281268 | |||||
Publication Statistics
PubMed Score 1286.80
PubMed score by year
PubTator Score 891.87
PubTator score by year
Related Publications
Text Mined References (175)
GeneRif Annotations (106)
Items per page:
0 of 0
PMID | Year | Title |
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