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Tbio
KRT10
Keratin, type I cytoskeletal 10

Protein Summary
Description
Plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization. This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269576
  • ENSP00000269576
  • ENSG00000186395

Symbol
  • KPP
  • BIE
  • EHK
  • K10
  • KPP
  • BCIE
  • CK10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
virus perturbation
0.95
cell type or tissue
0.86
hub protein
0.75
chemical
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 635.83   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 1410   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 635.83   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 1410   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Protein-Protein Interactions (90)
1 – 10 of 90
KRT1
Tbio
Novelty: 0.00344378
Score: 0.999
Data Source: STRINGDB
KRT77
Tbio
Novelty: 0.03118928
Score: 0.996
Data Source: STRINGDB
KRT5
Tbio
Novelty: 0.00122484
Score: 0.995
Data Source: STRINGDB
KRT2
Tbio
Novelty: 0.02059971
Score: 0.995
Data Source: STRINGDB
KRT16
Tbio
Novelty: 0.00602741
Score: 0.988
Data Source: STRINGDB
PRSS1
Tclin
Family: Enzyme
Novelty: 0.00182538
Score: 0.957
Data Source: STRINGDB
KRT7
Tbio
Novelty: 0.00064709
Score: 0.934
Data Source: STRINGDB
KRT8
Tbio
Novelty: 0.00128652
Score: 0.934
Data Source: STRINGDB
KRT72
Tbio
Novelty: 0.13561378
Score: 0.931
Data Source: STRINGDB
KRT4
Tbio
Novelty: 0.00704461
Score: 0.93
Data Source: STRINGDB
Publication Statistics
PubMed Score  635.83

PubMed score by year
PubTator Score  892.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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