Protein Summary
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]
- ENST00000309311
- ENSP00000307940
- ENSG00000167658
- EF2
- EF2
- EF-2
- EEF-2
- SCA26
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 1 | ||
protein domain | 1 | ||
kinase perturbation | 0.98 | ||
molecular function | 0.98 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1586.08 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 493 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1586.08 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 493 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1)
1 – 1 of 1
Protein-Protein Interactions (631)
1 – 10 of 631
FBXO9
Novelty: 0.2145394
p_int: 0.992246252
p_ni: 0.007753748
Score: 0.563
Data Source: BioPlex,STRINGDB
DEFA1
Novelty: 0.01027492
p_int: 0.991584763
p_ni: 0.008415237
Data Source: BioPlex
EEF2KMT
Family: Enzyme
Novelty: 0.33892681
p_int: 0.894189881
p_ni: 0.105810119
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
SLC25A48
Family: Transporter
Novelty: 1.08167819
p_int: 0.764772671
p_ni: 0.235227329
Score: 0.267
Data Source: BioPlex,STRINGDB
RPL6
Novelty: 0.01742007
Score: 0.999
Data Source: STRINGDB
RPL26
Novelty: 0.02077198
Score: 0.999
Data Source: STRINGDB
RPL7
Novelty: 0.00552644
Score: 0.999
Data Source: STRINGDB
RPL18A
Novelty: 0.04612948
Score: 0.999
Data Source: STRINGDB
RPL17
Novelty: 0.02730924
Score: 0.999
Data Source: STRINGDB
RPL10A
Novelty: 0.01747453
Score: 0.999
Data Source: STRINGDB
Pathways (21)
Reactome (15)
KEGG (2)
PathwayCommons (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 15
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | Eukaryotic Translation Elongation | ||||
Reactome | Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Reactome | Immune System | ||||
Reactome | Infectious disease | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Disease | ||||
Eukaryotic Translation Elongation | ||||
Gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
Immune System | ||||
Infectious disease | ||||
Gene Ontology Terms (40)
Functions (10)
Components (14)
Processes (16)
Items per page:
10
1 – 10 of 10
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 2 | 2 | 87.9 | |||||
red blood cell density measurement | 1 | 1 | 1 | 86.7 | |||||
mean reticulocyte volume | 1 | 2 | 2 | 84.6 | |||||
body mass index | 2 | 2 | 2 | 83.2 | |||||
erythrocyte count | 1 | 1 | 1 | 79 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 2 | 87.9 | |||||
red blood cell density measurement | 1 | 86.7 | |||||
mean reticulocyte volume | 2 | 84.6 | |||||
body mass index | 2 | 83.2 | |||||
erythrocyte count | 1 | 79 | |||||
Find similar targets by:
UniProt Keyword
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GWAS Trait
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MGI Phenotype
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|---|---|---|---|
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | eukaryotic translation elongation factor 2 | 100614367 | ||||||
Macaque | eukaryotic translation elongation factor 2 | 721806 | ||||||
Mouse | MGI:95288 | 13629 | ||||||
Rat | RGD:61979 | 29565 | ||||||
Dog | eukaryotic translation elongation factor 2 | VGNC:40209 | 476744 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | eukaryotic translation elongation factor 2 | |||||
Macaque | eukaryotic translation elongation factor 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | eukaryotic translation elongation factor 2 | |||||
Publication Statistics
PubMed Score 1586.08
PubMed score by year
PubTator Score 452.50
PubTator score by year