Tchem EEF2 Elongation factor 2

Protein Summary

Description

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P13639
• B2RMP5
• D6W618
• Q58J86
• EF-2

Gene Name

• EEF2

Ensembl ID

• ENST00000309311
• ENSP00000307940
• ENSG00000167658

Symbol

• EF2
• EF2
• EF-2
• EEF-2
• SCA26

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
protein domain	1
kinase perturbation	0.98
molecular function	0.98

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Elongation Factor 2

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Elongation Factor 2

Protein / Hydrolase / Elongation Factor 2

Protein / Enzyme Modulator / G-protein / Elongation Factor 2

DTO Classes

Protein / Enzyme / Hydrolase / Elongation Factor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1586.08   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 493   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1586.08   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 493   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (1)

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1 – 1 of 1

M5717

EEF2Tchem

pEC50 : 9

Protein-Protein Interactions (631)

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1 – 10 of 631

• See Interactions on String-DB

FBXO9

Tbio

Novelty:  0.2145394

p_int:  0.992246252

p_ni:  0.007753748

Score:  0.563

Data Source:  BioPlex,STRINGDB

DEFA1

Tbio

Novelty:  0.01027492

p_int:  0.991584763

p_ni:  0.008415237

Data Source:  BioPlex

EEF2KMT

Tdark

Family:  Enzyme

Novelty:  0.33892681

p_int:  0.894189881

p_ni:  0.105810119

Score:  0.986

Data Source:  BioPlex,Reactome,STRINGDB

SLC25A48

Tdark

Family:  Transporter

Novelty:  1.08167819

p_int:  0.764772671

p_ni:  0.235227329

Score:  0.267

Data Source:  BioPlex,STRINGDB

RPL6

Tbio

Novelty:  0.01742007

Score:  0.999

Data Source:  STRINGDB

RPL26

Tbio

Novelty:  0.02077198

Score:  0.999

Data Source:  STRINGDB

RPL17

Tbio

Novelty:  0.02730924

Score:  0.999

Data Source:  STRINGDB

RPL7

Tbio

Novelty:  0.00552644

Score:  0.999

Data Source:  STRINGDB

RPL18A

Tbio

Novelty:  0.04612948

Score:  0.999

Data Source:  STRINGDB

RPL10A

Tbio

Novelty:  0.01747453

Score:  0.999

Data Source:  STRINGDB

Nearest Tclin Targets (1)

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Upstream (1)

1 – 1 of 1

ADRA1A

Tclin

Family:  GPCR

KEGG Distance:  3

Common Pathways:  1

1: AMPK signaling pathway

Pathways (21)

Reactome (15)

KEGG (2)

PathwayCommons (1)

WikiPathways (3)

Disease (R-HSA-1643685)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Eukaryotic Translation Elongation	96 targets	R-HSA-156842
Reactome	Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Infectious disease	408 targets	R-HSA-5663205

Name	Explore in Pharos	Explore in Source
Disease	1105 targets	R-HSA-1643685
Eukaryotic Translation Elongation	96 targets	R-HSA-156842
Gamma carboxylation, hypusine formation and arylsulfatase activation	39 targets	R-HSA-163841
Immune System	2246 targets	R-HSA-168256
Infectious disease	408 targets	R-HSA-5663205

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (40)

Functions (10)

Components (14)

Processes (16)

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GO Term	Evidence	Assigned by
protein kinase binding	Inferred from Physical Interaction (IPI)	UniProtKB
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
translation elongation factor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
5S rRNA binding	Inferred from Electronic Annotation (IEA)	Ensembl
actin filament binding	Inferred from Electronic Annotation (IEA)	Ensembl
GTP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
GTPase activity	Inferred from Electronic Annotation (IEA)	Ensembl
p53 binding	Inferred from Electronic Annotation (IEA)	Ensembl
ribosome binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (18)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	1	2	2		87.9
red blood cell density measurement	EFO_0007978	1	1	1		86.7
mean reticulocyte volume	EFO_0010701	1	2	2		84.6
body mass index	EFO_0004340	2	2	2		83.2
erythrocyte count	EFO_0004305	1	1	1		79

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	2		87.9
red blood cell density measurement	EFO_0007978	1		86.7
mean reticulocyte volume	EFO_0010701	2		84.6
body mass index	EFO_0004340	2		83.2
erythrocyte count	EFO_0004305	1		79

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Elongation factor
GTP-binding
Isopeptide bond
Methylation

GWAS Trait Find Similar Targets

No Header	No Header
blood protein measurement
body height
body mass index
chronic lymphocytic leukemia
cigarettes per day measurement
creatinine measurement
eosinophil count
eosinophil percentage of leukocytes
erythrocyte count
glomerular filtration rate

MGI Phenotype Find Similar Targets

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cellular phenotype
embryo phenotype
growth/size/body region phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	eukaryotic translation elongation factor 2		100614367
Macaque	eukaryotic translation elongation factor 2		721806
Mouse	eukaryotic translation elongation factor 2	MGI:95288	13629
Rat	eukaryotic translation elongation factor 2	RGD:61979	29565
Dog	eukaryotic translation elongation factor 2	VGNC:40209	476744

Species	Name	OMA	EggNOG	Inparanoid
Chimp	eukaryotic translation elongation factor 2
Macaque	eukaryotic translation elongation factor 2
Mouse	eukaryotic translation elongation factor 2
Rat	eukaryotic translation elongation factor 2
Dog	eukaryotic translation elongation factor 2

Publication Statistics

PubMed Score 1586.08

PubMed score by year

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PubTator Score 452.50

PubTator score by year

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Related Publications

Text Mined References (67)

GeneRif Annotations (28)

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PMID	Year	Title