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Tclin
RARG
Retinoic acid receptor gamma

Protein Summary
Description
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbou ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338561
  • ENSP00000343698
  • ENSG00000172819
  • ENST00000394426
  • ENSP00000377947
  • ENST00000425354
  • ENSP00000388510
  • ENST00000543726
  • ENSP00000444335

Symbol
  • NR1B3
  • RARC
  • NR1B3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
molecular function
0.98
PubMedID
0.95
protein domain
0.85
histone modification site profile
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.59   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.59   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 106
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
1
1
43.8
self reported educational attainment
1
1
1
33.4
intelligence
1
1
1
33.4
1
1
1
33.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
43.8
self reported educational attainment
1
33.4
intelligence
1
33.4
1
33.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinoic acid receptor gamma
VGNC:8514
451935
Macaque
retinoic acid receptor gamma
699532
Mouse
MGI:97858
19411
Rat
RGD:1583230
685072
Dog
retinoic acid receptor gamma
VGNC:45353
486508
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinoic acid receptor gamma
Macaque
retinoic acid receptor gamma
Mouse
Rat
Dog
retinoic acid receptor gamma
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P13631-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (45)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (53)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (132)
1 – 10 of 132
RARA
Tclin
Family: NR
Novelty: 0.00080574
p_int: 1
Score: 0.985
Data Source: BioPlex,STRINGDB
PNMA8A
Tdark
Novelty: 0.95674878
p_int: 0.999999924
p_ni: 6.1e-8
p_wrong: 1.6e-8
Score: 0.269
Data Source: BioPlex,STRINGDB
RXRB
Tclin
Family: NR
Novelty: 0.01503977
p_int: 0.999998109
p_ni: 0.000001781
p_wrong: 1.1e-7
Score: 0.996
Data Source: BioPlex,STRINGDB
ZPLD1
Tbio
Novelty: 0.19418088
p_int: 0.999937573
p_ni: 0.000062422
p_wrong: 5e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
KCNJ6
Tchem
Family: IC
Novelty: 0.00330353
p_int: 0.998266646
p_ni: 0.001733354
Score: 0.228
Data Source: BioPlex,STRINGDB
RBL2
Tbio
Novelty: 0.00121893
p_int: 0.995769365
p_ni: 0.004129688
p_wrong: 0.000100946
Score: 0.241
Data Source: BioPlex,STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.987
Data Source: Reactome,STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
Score: 0.986
Data Source: STRINGDB
NCOR1
Tchem
Family: TF
Novelty: 0.0021926
Score: 0.986
Data Source: STRINGDB
NCOR2
Tchem
Family: TF
Novelty: 0.00066449
Score: 0.986
Data Source: STRINGDB
Publication Statistics
PubMed Score  129.59

PubMed score by year
PubTator Score  211.49

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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