You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
ITGA4
Integrin alpha-4

Protein Summary
Description
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). The gene encodes a member of the integr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339307
  • ENSP00000340149
  • ENSG00000115232
  • ENST00000397033
  • ENSP00000380227

Symbol
  • CD49D
  • IA4
  • CD49D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
interacting protein
0.92
cellular component
0.79
biological term
0.77
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 411.06   (req: < 5)
Gene RIFs: 187   (req: <= 3)
Antibodies: 1835   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 411.06   (req: >= 5)
Gene RIFs: 187   (req: > 3)
Antibodies: 1835   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 121
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
natalizumab
no chemical structure image available
vedolizumab
no chemical structure image available
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
6
7
8
98.4
leukocyte count
2
2
2
91.9
reticulocyte count
5
3
5
75.6
monocyte percentage of leukocytes
2
2
3
75.6
reticulocyte measurement
3
2
3
72.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
8
98.4
leukocyte count
2
91.9
reticulocyte count
5
75.6
monocyte percentage of leukocytes
3
75.6
reticulocyte measurement
3
72.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 4
VGNC:2704
470596
Macaque
integrin subunit alpha 4
704745
Mouse
MGI:96603
16401
Rat
RGD:1593249
311144
Dog
integrin subunit alpha 4
VGNC:42126
488429
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 4
Macaque
integrin subunit alpha 4
Mouse
Rat
Dog
integrin subunit alpha 4
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P13612-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (44)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cell surface interactions at the vascular wall
Reactome
Extracellular matrix organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cell surface interactions at the vascular wall
Extracellular matrix organization
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (36)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (260)
1 – 10 of 260
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.999347776
p_ni: 0.000652224
Score: 0.406
Data Source: BioPlex,STRINGDB
CST9
Tbio
Novelty: 0.08129086
p_int: 0.998446921
p_ni: 0.001553079
Score: 0.237
Data Source: BioPlex,STRINGDB
BTNL8
Tdark
Novelty: 0.40339869
p_int: 0.99581156
p_ni: 0.004187797
p_wrong: 6.43e-7
Data Source: BioPlex
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.995172481
p_ni: 0.004827519
Score: 0.226
Data Source: BioPlex,STRINGDB
PTCH1
Tbio
Novelty: 0.00077635
p_int: 0.99456638
p_ni: 0.005215166
p_wrong: 0.000218454
Data Source: BioPlex
PON2
Tbio
Family: Enzyme
Novelty: 0.00414855
p_int: 0.983720088
p_ni: 0.016279912
Data Source: BioPlex
HYOU1
Tbio
Novelty: 0.00833649
p_int: 0.979569996
p_ni: 0.020425941
p_wrong: 0.000004064
Data Source: BioPlex
FAM19A2
Tbio
Novelty: 0.28999346
p_int: 0.974015755
p_ni: 0.023807286
p_wrong: 0.002176959
Data Source: BioPlex
NAAA
Tchem
Family: Enzyme
Novelty: 0.00368876
p_int: 0.969295775
p_ni: 0.030703748
p_wrong: 4.77e-7
Data Source: BioPlex
PRSS2
Tchem
Family: Enzyme
Novelty: 0.00959404
p_int: 0.957084011
p_ni: 0.042682596
p_wrong: 0.000233392
Score: 0.178
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  411.06

PubMed score by year
PubTator Score  248.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: