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Tbio
VCAN
Versican core protein

Protein Summary
Description
May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265077
  • ENSP00000265077
  • ENSG00000038427
  • ENST00000342785
  • ENSP00000342768
  • ENST00000343200
  • ENSP00000340062
  • ENST00000502527
  • ENSP00000421362

Symbol
  • CSPG2
  • WGN
  • ERVR
  • GHAP
  • PG-M
  • WGN1
  • CSPG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
1
gene perturbation
0.99
kinase perturbation
0.97
PubMedID
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 929.63   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 296   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 929.63   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
3
5
99
white matter integrity
4
3
4
97
cortical surface area measurement
1
1
0
7
86.5
body fat distribution
2
1
4
65.7
monocyte count
1
1
1
43.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
5
99
white matter integrity
4
97
cortical surface area measurement
0
7
86.5
body fat distribution
4
65.7
monocyte count
1
43.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
versican
VGNC:4221
461766
Macaque
versican
712365
Mouse
MGI:102889
13003
Rat
RGD:619940
114122
Dog
versican
VGNC:48241
488922
Species
Name
OMA
EggNOG
Inparanoid
Chimp
versican
Macaque
versican
Mouse
Rat
Dog
versican
Pathways (32)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
CS/DS degradation
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
CS/DS degradation
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Gene Ontology Terms (25)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (251)
1 – 10 of 251
TNFAIP6
Tbio
Novelty: 0.0046811
p_int: 0.99999999
p_ni: 9e-9
p_wrong: 1e-9
Score: 0.291
Data Source: BioPlex,STRINGDB
CD44
Tbio
Novelty: 0.00011321
p_int: 0.999999564
p_ni: 4.35e-7
p_wrong: 1e-9
Score: 0.844
Data Source: BioPlex,STRINGDB
BCAN
Tbio
Novelty: 0.00737982
p_int: 0.99999445
p_ni: 0.000005493
p_wrong: 5.7e-8
Score: 0.972
Data Source: BioPlex,STRINGDB
IL17F
Tbio
Novelty: 0.00223549
p_int: 0.999991361
p_ni: 0.000008633
p_wrong: 6e-9
Data Source: BioPlex
FAM19A4
Tbio
Novelty: 0.04305684
p_int: 0.999990262
p_ni: 0.000009714
p_wrong: 2.4e-8
Score: 0.175
Data Source: BioPlex,STRINGDB
MSMB
Tbio
Novelty: 0.00241546
p_int: 0.99388468
p_ni: 0.003325052
p_wrong: 0.002790269
Data Source: BioPlex
BGN
Tbio
Novelty: 0.00139486
Score: 0.985
Data Source: STRINGDB
DCN
Tbio
Novelty: 0.00073027
Score: 0.985
Data Source: STRINGDB
FBN1
Tbio
Novelty: 0.00074957
Score: 0.983
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  929.63

PubMed score by year
PubTator Score  264.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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