CFTR
Cystic fibrosis transmembrane conductance regulator
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
chemical | 1 | ||
molecular function | 1 | ||
kinase perturbation | 0.95 | ||
biological process | 0.94 | ||
hub protein | 0.94 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | ABC transporter disorders | ||||
Reactome | ABC-family proteins mediated transport | ||||
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Defective CFTR causes cystic fibrosis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
ABC transporter disorders | ||||
ABC-family proteins mediated transport | ||||
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Defective CFTR causes cystic fibrosis | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 4 | 5 | 6 | 87.3 | |||||
waist-hip ratio | 3 | 4 | 5 | 86.6 | |||||
Dupuytren Contracture | 2 | 2 | 0 | 1.2 | 77 | ||||
2 | 2 | 0 | 1.2 | 52.3 | |||||
1 | 1 | 0 | 1.2 | 38.8 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 6 | 87.3 | |||||
waist-hip ratio | 5 | 86.6 | |||||
Dupuytren Contracture | 0 | 1.2 | 77 | ||||
0 | 1.2 | 52.3 | |||||
0 | 1.2 | 38.8 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cystic fibrosis transmembrane conductance regulator | 463674 | ||||||
Macaque | cystic fibrosis transmembrane conductance regulator | 574346 | ||||||
Mouse | MGI:88388 | 12638 | ||||||
Rat | RGD:2332 | 24255 | ||||||
Dog | cystic fibrosis transmembrane conductance regulator | VGNC:39180 | 492302 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cystic fibrosis transmembrane conductance regulator | |||||
Macaque | cystic fibrosis transmembrane conductance regulator | |||||
Mouse | ||||||
Rat | ||||||
Dog | cystic fibrosis transmembrane conductance regulator | |||||
PMID | Year | Title |
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