CFTR
Cystic fibrosis transmembrane conductance regulator
Protein Summary
Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:15010471, PubMed:12588899, PubMed:17036051, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:1712898, PubMed:8910473, PubMed:9804160, PubMed:12529365, PubMed:17182731, PubMed:26846474, PubMed:28087700). Channel activity is coupled to ATP hydrolysis (PubMed:8910473). The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22178883, PubMed:22121115, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contr ...more
- ENST00000003084
- ENSP00000003084
- ENSG00000001626
- ENST00000649781
- ENSP00000497203
- ABCC7
- CF
- MRP7
- ABC35
- ABCC7
- CFTR/MRP
- TNR-CFTR
- dJ760C5.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
molecular function | 1 | ||
kinase perturbation | 0.95 | ||
biological process | 0.94 | ||
hub protein | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8818.85 (req: < 5)
Gene RIFs: 1206 (req: <= 3)
Antibodies: 999 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8818.85 (req: >= 5)
Gene RIFs: 1206 (req: > 3)
Antibodies: 999 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 34
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 366
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 7
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (7)
Active Ligands (366)
Protein-Protein Interactions (502)
Nearest Tclin Targets
Pathways (26)
Reactome (18)
KEGG (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ABC transporter disorders | ||||
Reactome | ABC-family proteins mediated transport | ||||
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Defective CFTR causes cystic fibrosis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ABC transporter disorders | ||||
ABC-family proteins mediated transport | ||||
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Defective CFTR causes cystic fibrosis | ||||
Viral Interactions (0)
Gene Ontology Terms (54)
Functions (14)
Components (20)
Processes (20)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 4 | 5 | 6 | 87.3 | |||||
waist-hip ratio | 3 | 4 | 5 | 86.6 | |||||
Dupuytren Contracture | 2 | 2 | 0 | 1.2 | 77 | ||||
2 | 2 | 0 | 1.2 | 52.3 | |||||
1 | 1 | 0 | 1.2 | 38.8 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 6 | 87.3 | |||||
waist-hip ratio | 5 | 86.6 | |||||
Dupuytren Contracture | 0 | 1.2 | 77 | ||||
0 | 1.2 | 52.3 | |||||
0 | 1.2 | 38.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cystic fibrosis transmembrane conductance regulator | 463674 | ||||||
Macaque | cystic fibrosis transmembrane conductance regulator | 574346 | ||||||
Mouse | MGI:88388 | 12638 | ||||||
Rat | RGD:2332 | 24255 | ||||||
Dog | cystic fibrosis transmembrane conductance regulator | VGNC:39180 | 492302 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cystic fibrosis transmembrane conductance regulator | |||||
Macaque | cystic fibrosis transmembrane conductance regulator | |||||
Mouse | ||||||
Rat | ||||||
Dog | cystic fibrosis transmembrane conductance regulator | |||||
Publication Statistics
PubMed Score 8818.85
PubMed score by year
PubTator Score 6138.35
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (1526)
GeneRif Annotations (1206)
Items per page:
0 of 0
PMID | Year | Title |
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