Tbio MYH8 Myosin-8

Protein Summary

Description

Muscle contraction. Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is predominantly expressed in fetal skeletal muscle. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• P13535
• Q14910

Gene Name

• MYH8

Ensembl ID

• ENST00000403437
• ENSP00000384330
• ENSG00000133020

Symbol

• DA7
• MyHC-pn
• gtMHC-F
• MyHC-peri

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
gene perturbation	0.98
protein domain	0.85
cell type or tissue	0.7
cellular component	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.02   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.02   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (140)

Explore Interacting Targets

1 – 10 of 140

• See Interactions on String-DB

ABTB2

Tdark

Novelty:  0.45729157

p_int:  0.999999983

p_ni:  1.7e-8

Data Source:  BioPlex

TLE3

Tbio

Novelty:  0.02641884

p_int:  0.999999967

p_ni:  2e-9

p_wrong:  3.1e-8

Score:  0.199

Data Source:  BioPlex,STRINGDB

MECOM

Tbio

Family:  TF; Epigenetic

Novelty:  0.00500501

p_int:  0.999999957

p_ni:  4.3e-8

Data Source:  BioPlex

RSPH6A

Tdark

Novelty:  0.03734897

p_int:  0.999999953

p_ni:  4.7e-8

Data Source:  BioPlex

LZTR1

Tbio

Novelty:  0.02363333

p_int:  0.999994977

p_ni:  0.000005023

Data Source:  BioPlex

AURKC

Tchem

Family:  Kinase

Novelty:  0.00950433

p_int:  0.999992659

p_ni:  0.000007341

Score:  0.313

Data Source:  BioPlex,STRINGDB

HIST1H4A

Tchem

Novelty:  0.00279614

p_int:  0.999979525

p_ni:  0.000020224

p_wrong:  2.51e-7

Data Source:  BioPlex

ROGDI

Tbio

Novelty:  0.077277

p_int:  0.996964407

p_ni:  0.000093057

p_wrong:  0.002942536

Score:  0.261

Data Source:  BioPlex,STRINGDB

KLHL9

Tdark

Novelty:  0.22434722

p_int:  0.943151646

p_ni:  0.056847357

p_wrong:  9.97e-7

Data Source:  BioPlex

TPM1

Tbio

Novelty:  0.00261206

Score:  0.992

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (17)

Reactome (2)

KEGG (1)

PathwayCommons (3)

WikiPathways (11)

Muscle contraction (R-HSA-397014)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Muscle contraction	202 targets	R-HSA-397014
Reactome	Striated Muscle Contraction	34 targets	R-HSA-390522

Name	Explore in Pharos	Explore in Source
Muscle contraction	202 targets	R-HSA-397014
Striated Muscle Contraction	34 targets	R-HSA-390522

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (8)

Components (5)

Processes (4)

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Items per page:

10

1 – 8 of 8

GO Term	Evidence	Assigned by
ATP binding	Inferred from Mutant Phenotype (IMP)	BHF-UCL
ATPase activity	Inferred from Mutant Phenotype (IMP)	BHF-UCL
microfilament motor activity	Inferred from Mutant Phenotype (IMP)	BHF-UCL
actin filament binding	Traceable Author Statement (TAS)	BHF-UCL
myosin light chain binding	Traceable Author Statement (TAS)	BHF-UCL
myosin phosphatase activity	Traceable Author Statement (TAS)	Reactome
structural constituent of muscle	Non-traceable Author Statement (NAS)	UniProtKB
calmodulin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Actin-binding
ATP-binding
Calmodulin-binding
Coiled coil
Complete proteome
Cytoplasm
Disease mutation
Methylation
Motor protein
Muscle protein

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	myosin heavy chain 8	VGNC:12482	455074
Mouse	myosin, heavy polypeptide 8, skeletal muscle, perinatal	MGI:1339712	17885
Dog	myosin heavy chain 8	VGNC:49929	403808
Cow	myosin heavy chain 8	VGNC:31797	281339
Xenopus	myosin, heavy chain 3, skeletal muscle, embryonic	XB-GENE-989276	448762

Species	Name	OMA	EggNOG	Inparanoid
Chimp	myosin heavy chain 8
Mouse	myosin, heavy polypeptide 8, skeletal muscle, perinatal
Dog	myosin heavy chain 8
Cow	myosin heavy chain 8
Xenopus	myosin, heavy chain 3, skeletal muscle, embryonic

Publication Statistics

PubMed Score 84.02

PubMed score by year

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PubTator Score 20.78

PubTator score by year

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Related Publications

Text Mined References (18)

GeneRif Annotations (8)

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10

0 of 0

PMID	Year	Title