Protein Summary
Muscle contraction. Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is predominantly expressed in fetal skeletal muscle. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. [provided by RefSeq, Sep 2009]
- ENST00000403437
- ENSP00000384330
- ENSG00000133020
- DA7
- MyHC-pn
- gtMHC-F
- MyHC-peri
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.99 | ||
gene perturbation | 0.98 | ||
protein domain | 0.85 | ||
cell type or tissue | 0.7 | ||
cellular component | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 84.02 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 57 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 84.02 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 57 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (140)
TLE3
Novelty: 0.02641884
p_int: 0.999999967
p_ni: 2e-9
p_wrong: 3.1e-8
Score: 0.199
Data Source: BioPlex,STRINGDB
MECOM
Family: TF; Epigenetic
Novelty: 0.00500501
p_int: 0.999999957
p_ni: 4.3e-8
Data Source: BioPlex
AURKC
Family: Kinase
Novelty: 0.00950433
p_int: 0.999992659
p_ni: 0.000007341
Score: 0.313
Data Source: BioPlex,STRINGDB
HIST1H4A
Novelty: 0.00279614
p_int: 0.999979525
p_ni: 0.000020224
p_wrong: 2.51e-7
Data Source: BioPlex
ROGDI
Novelty: 0.077277
p_int: 0.996964407
p_ni: 0.000093057
p_wrong: 0.002942536
Score: 0.261
Data Source: BioPlex,STRINGDB
KLHL9
Novelty: 0.22434722
p_int: 0.943151646
p_ni: 0.056847357
p_wrong: 9.97e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (17)
Reactome (2)
KEGG (1)
PathwayCommons (3)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Muscle contraction | ||||
Reactome | Striated Muscle Contraction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Muscle contraction | ||||
Striated Muscle Contraction | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (8)
Components (5)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | myosin heavy chain 8 | VGNC:12482 | 455074 | |||||
Mouse | MGI:1339712 | 17885 | ||||||
Dog | myosin heavy chain 8 | VGNC:49929 | 403808 | |||||
Cow | myosin heavy chain 8 | VGNC:31797 | 281339 | |||||
Xenopus | myosin, heavy chain 3, skeletal muscle, embryonic | XB-GENE-989276 | 448762 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | myosin heavy chain 8 | |||||
Mouse | ||||||
Dog | myosin heavy chain 8 | |||||
Cow | myosin heavy chain 8 | |||||
Xenopus | myosin, heavy chain 3, skeletal muscle, embryonic | |||||
Publication Statistics
PubMed Score 84.02
PubMed score by year
PubTator Score 20.78
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (8)
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