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Tbio
MYH6
Myosin-6

Protein Summary
Description
Muscle contraction. Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located approximately 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356287
  • ENSP00000348634
  • ENSG00000197616
  • ENST00000405093
  • ENSP00000386041

Symbol
  • MYHCA
  • ASD3
  • MYHC
  • SSS3
  • CMH14
  • MYHCA
  • CMD1EE
  • alpha-MHC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.85
biological process
0.73
cellular component
0.73
phenotype
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1925.45   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1925.45   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (239)
HIF1A
Tchem
Family:  TF
Novelty:  0.00011503
p_int:  1
Score:  0.45
Data Source:  BioPlex,STRINGDB
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.999999999
Data Source:  BioPlex
LZTR1
Tbio
Novelty:  0.02363333
p_int:  0.999999976
p_ni:  3e-9
p_wrong:  2.1e-8
Data Source:  BioPlex
TNNI1
Tbio
Novelty:  0.01639536
Score:  0.998
Data Source:  STRINGDB
ACTN2
Tbio
Novelty:  0.00615882
Score:  0.997
Data Source:  STRINGDB
TPM1
Tbio
Novelty:  0.00261206
Score:  0.996
Data Source:  STRINGDB
TPM2
Tbio
Novelty:  0.00406572
Score:  0.994
Data Source:  STRINGDB
MYBPC3
Tbio
Novelty:  0.00297478
Score:  0.992
Data Source:  Reactome,STRINGDB
TNNT2
Tbio
Novelty:  0.00044568
Score:  0.991
Data Source:  STRINGDB
MYL2
Tbio
Novelty:  0.0018887
Score:  0.991
Data Source:  Reactome,STRINGDB
Pathways (15)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (38)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
HGNC
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate
2
1
1
5.3
94.5
electrocardiography
2
1
61
5.3
94.2
pulse pressure measurement
2
2
2
92.5
resting heart rate
1
2
0
7.6
89.2
P wave terminal force measurement
1
1
0
133.5
89.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate
1
5.3
94.5
electrocardiography
61
5.3
94.2
pulse pressure measurement
2
92.5
resting heart rate
0
7.6
89.2
P wave terminal force measurement
0
133.5
89.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin heavy chain 6
452801
Mouse
MGI:97255
17888
Rat
RGD:62029
29556
Cow
myosin, heavy chain 6, cardiac muscle, alpha
100296004
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin heavy chain 6
Mouse
Rat
Cow
myosin, heavy chain 6, cardiac muscle, alpha
Publication Statistics
PubMed Score 1925.45
PubMed score by year
PubTator Score 271.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title