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Tchem
CCL5
C-C motif chemokine 5

Protein Summary
Description
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilizat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000603197
  • ENSP00000474412
  • ENSG00000271503
  • ENST00000605140
  • ENSP00000475057
  • ENST00000613606
  • ENSP00000479894
  • ENSG00000274233
  • ENST00000618639
  • ENSP00000484921

Symbol
  • D17S136E
  • SCYA5
  • SISd
  • eoCP
  • SCYA5
  • RANTES
  • TCP228
  • D17S136E
  • SIS-delta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
disease
1
molecular function
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2965.99   (req: < 5)
Gene RIFs: 462   (req: <= 3)
Antibodies: 882   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2965.99   (req: >= 5)
Gene RIFs: 462   (req: > 3)
Antibodies: 882   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 79
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (17)
1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (94)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (82)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (535)
1 – 10 of 535
C4A
Tbio
Novelty: 0.00062793
p_int: 0.996994267
p_ni: 0.002485949
p_wrong: 0.000519783
Score: 0.357
Data Source: BioPlex,STRINGDB
NTMT1
Tbio
Family: Enzyme
Novelty: 0.06322967
p_int: 0.990960426
p_ni: 0.002723153
p_wrong: 0.006316421
Score: 0.209
Data Source: BioPlex,STRINGDB
SPATA20
Tdark
Novelty: 0.34126403
p_int: 0.974397089
p_ni: 0.025602911
Score: 0.169
Data Source: BioPlex,STRINGDB
AK4
Tbio
Family: Kinase
Novelty: 0.00977619
p_int: 0.951429026
p_ni: 0.048570782
p_wrong: 1.92e-7
Score: 0.209
Data Source: BioPlex,STRINGDB
UBAC1
Tbio
Novelty: 0.00122518
p_int: 0.862306437
p_ni: 0.137681568
p_wrong: 0.000011995
Data Source: BioPlex
SPRYD4
Tdark
Novelty: 0.44404169
p_int: 0.847877884
p_ni: 0.152100524
p_wrong: 0.000021592
Score: 0.252
Data Source: BioPlex,STRINGDB
GPD1L
Tbio
Family: Enzyme
Novelty: 0.0169606
p_int: 0.836233293
p_ni: 0.163766707
Score: 0.188
Data Source: BioPlex,STRINGDB
S100A13
Tbio
Novelty: 0.0283577
p_int: 0.770910481
p_ni: 0.229083869
p_wrong: 0.00000565
Score: 0.235
Data Source: BioPlex,STRINGDB
CCR5
Tclin
Family: GPCR
Novelty: 0.00022549
Score: 0.999
Data Source: Reactome,STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score  2965.99

PubMed score by year
PubTator Score  1737.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer