Tbio RNH1 Ribonuclease inhibitor

Protein Summary

Description

Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis. Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]

Uniprot Accession IDs

• P13489
• Q8IZK8
• Q96FD7
• Q9BQ80
• Q9UDK6

Gene Name

• RNH1

Ensembl ID

• ENST00000354420
• ENSP00000346402
• ENSG00000023191
• ENST00000356187
• ENSP00000348515
• ENST00000397604
• ENSP00000380729
• ENST00000397614
• ENSP00000380738
• ENST00000397615
• ENSP00000380739
• ENST00000438658
• ENSP00000416589
• ENST00000533410
• ENSP00000435594
• ENST00000534797
• ENSP00000433999
• ENST00000612988
• ENSP00000479004
• ENSG00000276230
• ENST00000617351
• ENSP00000484572
• ENST00000618184
• ENSP00000478664
• ENST00000619599
• ENSP00000479966
• ENST00000621211
• ENSP00000480036
• ENST00000632527
• ENSP00000487940
• ENST00000632954
• ENSP00000487753
• ENST00000633287
• ENSP00000488734

Symbol

• PRI
• RNH
• RAI
• RNH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
transcription factor	0.88
transcription factor binding site profile	0.83
tissue sample	0.72
interacting protein	0.63

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Ribonuclease Inhibitor

Protein / Nucleic Acid Binding / Ribonuclease Inhibitor

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Ribonuclease Inhibitor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 558.93   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 411   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 558.93   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0