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Tbio
TDGF1
Teratocarcinoma-derived growth factor 1

Protein Summary
Description
GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953). This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296145
  • ENSP00000296145
  • ENSG00000241186

Symbol
  • CRIPTO
  • CR
  • CR-1
  • CRGF
  • CRIPTO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
cellular component
0.69
PubMedID
0.61
microRNA
0.6
biological term
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.25   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 602   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.25   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 602   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Reactome
Regulation of signaling by NODAL
Reactome
Signaling by NODAL
Reactome
Transcriptional regulation of pluripotent stem cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Regulation of signaling by NODAL
Signaling by NODAL
Transcriptional regulation of pluripotent stem cells
Gene Ontology Terms (39)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (117)
1 – 10 of 117
RMND5B
Tbio
Novelty: 0.08447048
p_int: 0.999755921
p_ni: 0.00010337
p_wrong: 0.000140709
Score: 0.2
Data Source: BioPlex,STRINGDB
IL18
Tbio
Novelty: 0.00022844
p_int: 0.999090533
p_ni: 0.00089975
p_wrong: 0.000009716
Score: 0.189
Data Source: BioPlex,STRINGDB
GID4
Tbio
Novelty: 0.05252674
p_int: 0.99888559
p_ni: 0.00111441
Score: 0.232
Data Source: BioPlex,STRINGDB
ZMYND19
Tdark
Novelty: 0.3590069
p_int: 0.998879813
p_ni: 0.001120187
Score: 0.666
Data Source: BioPlex,STRINGDB
ARMC8
Tbio
Novelty: 0.06820746
p_int: 0.994210067
p_ni: 0.005789933
Score: 0.303
Data Source: BioPlex,STRINGDB
GID8
Tbio
Novelty: 0.21243963
p_int: 0.987881985
p_ni: 0.012118015
Score: 0.547
Data Source: BioPlex,STRINGDB
RMND5A
Tbio
Novelty: 0.01820349
p_int: 0.981919523
p_ni: 0.018080477
Score: 0.813
Data Source: BioPlex,STRINGDB
MKLN1
Tbio
Novelty: 0.05014385
p_int: 0.969673768
p_ni: 0.030326232
Score: 0.303
Data Source: BioPlex,STRINGDB
AIP
Tbio
Novelty: 0.00869592
p_int: 0.966939174
p_ni: 0.033060826
Score: 0.198
Data Source: BioPlex,STRINGDB
WDR26
Tbio
Novelty: 0.04140166
p_int: 0.945804094
p_ni: 0.054195906
Score: 0.562
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  223.25

PubMed score by year
PubTator Score  45.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer