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Tbio
HOXD8
Homeobox protein Hox-D8

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313173
  • ENSP00000315949
  • ENSG00000175879
  • ENST00000450510
  • ENSP00000409026

Symbol
  • HOX4E
  • HOX4
  • HOX4E
  • HOX5.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue sample
0.71
biological process
0.69
PubMedID
0.68
cell type or tissue
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.74   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.74   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (22)
1 – 10 of 22
HOXD9
Tbio
Family:  TF
Novelty:  0.01789716
Score:  0.702
Data Source:  STRINGDB
HOXD3
Tbio
Family:  TF
Novelty:  0.02148544
Score:  0.596
Data Source:  STRINGDB
HOXD10
Tbio
Family:  TF
Novelty:  0.01137819
Score:  0.562
Data Source:  STRINGDB
HOXD4
Tbio
Family:  TF
Novelty:  0.01675267
Score:  0.52
Data Source:  STRINGDB
HOXC9
Tbio
Family:  TF
Novelty:  0.02524418
Score:  0.513
Data Source:  STRINGDB
HOXA11
Tbio
Family:  TF
Novelty:  0.00745145
Score:  0.497
Data Source:  STRINGDB
TBX15
Tbio
Family:  TF
Novelty:  0.03198241
Score:  0.494
Data Source:  STRINGDB
HOXC10
Tbio
Family:  TF
Novelty:  0.02817778
Score:  0.485
Data Source:  STRINGDB
HOXD13
Tbio
Family:  TF
Novelty:  0.00404722
Score:  0.473
Data Source:  STRINGDB
HOXD11
Tbio
Family:  TF
Novelty:  0.0195888
Score:  0.469
Data Source:  STRINGDB
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
3
3
4
92.9
balding measurement
1
3
3
92.9
glomerular filtration rate
5
3
5
7.7
92.6
urate measurement
3
3
4
85.7
hematocrit
3
1
3
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
4
92.9
balding measurement
3
92.9
glomerular filtration rate
5
7.7
92.6
urate measurement
4
85.7
hematocrit
3
82.3
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeobox D8
VGNC:1967
459763
Macaque
homeobox D8
106992624
Mouse
MGI:96209
15437
Dog
homeobox D8
VGNC:41766
100687992
Horse
homeobox D8
VGNC:51460
100629949
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeobox D8
Macaque
homeobox D8
Mouse
Dog
homeobox D8
Horse
homeobox D8
Publication Statistics
PubMed Score 26.74
PubMed score by year
PubTator Score 15.19
PubTator score by year