Tbio MYF5 Myogenic factor 5

Protein Summary

Description

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

Uniprot Accession IDs

• P13349
• Q6ISR9
• Myf-5

Gene Name

• MYF5

Ensembl ID

• ENST00000228644
• ENSP00000228644
• ENSG00000111049

Symbol

• BHLHC2
• EORVA
• bHLHc2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.9
molecular function	0.84
tissue	0.69
virus perturbation	0.68
phenotype	0.63

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Myogenic Factor 5

Protein / Nucleic Acid Binding / Myogenic Factor 5

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Myogenic Factor 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448.73   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 424   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448.73   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 424   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0