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Tbio
CCL4
C-C motif chemokine 4

Protein Summary
Description
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000615863
  • ENSP00000482259
  • ENSG00000275302
  • ENST00000617322
  • ENSP00000480345
  • ENSG00000275824
  • ENST00000621600
  • ENSP00000478708
  • ENSG00000277943

Symbol
  • LAG1
  • MIP1B
  • SCYA4
  • ACT2
  • G-26
  • HC21
  • LAG1
  • LAG-1
  • MIP1B
  • SCYA2
  • SCYA4
  • MIP1B1
  • AT744.1
  • MIP-1-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
chemical
0.94
gene perturbation
0.9
biological term
0.79
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1262.25   (req: < 5)
Gene RIFs: 108   (req: <= 3)
Antibodies: 551   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1262.25   (req: >= 5)
Gene RIFs: 108   (req: > 3)
Antibodies: 551   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-C motif chemokine 3 measurement
1
1
1
81.7
C-C motif chemokine 3 measurement
1
1
1
81.7
C-C motif chemokine 3 measurement
1
1
1
81.7
Items per page:
1 – 3 of 3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-C motif chemokine 3 measurement
1
81.7
C-C motif chemokine 3 measurement
1
81.7
C-C motif chemokine 3 measurement
1
81.7
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (26)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Immune System
Reactome
Interleukin-10 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
G alpha (i) signalling events
GPCR downstream signalling
Immune System
Interleukin-10 signaling
Gene Ontology Terms (32)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (442)
1 – 10 of 442
ATP5S
Tbio
Family: Enzyme
Novelty: 0.15637839
p_int: 0.999999999
p_ni: 1e-9
Score: 0.379
Data Source: BioPlex,STRINGDB
AMZ2
Tdark
Family: Enzyme
Novelty: 0.27424719
p_int: 0.999664753
p_ni: 0.000335247
Score: 0.309
Data Source: BioPlex,STRINGDB
PEX14
Tbio
Novelty: 0.0210557
p_int: 0.999095236
p_ni: 0.000904764
Score: 0.248
Data Source: BioPlex,STRINGDB
CCR5
Tclin
Family: GPCR
Novelty: 0.00022549
Score: 0.997
Data Source: Reactome,STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.991
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.991
Data Source: STRINGDB
CCR1
Tchem
Family: GPCR
Novelty: 0.00218065
Score: 0.989
Data Source: Reactome,STRINGDB
CXCL9
Tbio
Novelty: 0.00073213
Score: 0.985
Data Source: STRINGDB
CCL3
Tbio
Novelty: 0.00049216
Score: 0.983
Data Source: STRINGDB
CCR3
Tchem
Family: GPCR
Novelty: 0.00197059
Score: 0.983
Data Source: STRINGDB
Publication Statistics
PubMed Score  1262.25

PubMed score by year
PubTator Score  1547.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer