Tbio CCL4 C-C motif chemokine 4

Protein Summary

Description

Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• P13236
• P22617
• Q13704
• Q3SXL8
• Q6FGI8

Gene Name

• CCL4

Ensembl ID

• ENST00000615863
• ENSP00000482259
• ENSG00000275302
• ENST00000617322
• ENSP00000480345
• ENSG00000275824
• ENST00000621600
• ENSP00000478708
• ENSG00000277943

Symbol

• LAG1
• MIP1B
• SCYA4
• ACT2
• G-26
• HC21
• LAG1
• LAG-1
• MIP1B
• SCYA2
• SCYA4
• MIP1B1
• AT744.1
• MIP-1-beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.98
chemical	0.94
gene perturbation	0.9
biological term	0.79
virus perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / C-c Motif Chemokine 4

DTO Classes

Protein / Signaling / Chemokine / C-c Motif Chemokine 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1519.3   (req: < 5)

Gene RIFs: 129   (req: <= 3)

Antibodies: 551   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1519.3   (req: >= 5)

Gene RIFs: 129   (req: > 3)

Antibodies: 551   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0