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Tbio
IFITM1
Interferon-induced transmembrane protein 1

Protein Summary
Description
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328221
  • ENSP00000330825
  • ENSG00000185885
  • ENST00000408968
  • ENSP00000386187
  • ENST00000528780
  • ENSP00000437057

Symbol
  • CD225
  • IFI17
  • 9-27
  • CD225
  • IFI17
  • LEU13
  • DSPA2a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
virus perturbation
1
small molecule perturbation
0.99
transcription factor perturbation
0.98
gene perturbation
0.73


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.5   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.5   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon induced transmembrane protein 1
VGNC:1071
100526663
Macaque
interferon induced transmembrane protein 1
697687
Cow
interferon induced transmembrane protein 2 (1-8D)
615833
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon induced transmembrane protein 1
Macaque
interferon induced transmembrane protein 1
Cow
interferon induced transmembrane protein 2 (1-8D)
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P13164-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Reactome
Interferon Signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cytokine Signaling in Immune system
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Interferon Signaling
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (160)
1 – 10 of 160
MX1
Tbio
Novelty: 0.00072554
Score: 0.991
Data Source: STRINGDB
ISG15
Tbio
Novelty: 0.00203781
Score: 0.989
Data Source: STRINGDB
IFI6
Tbio
Novelty: 0.02590679
Score: 0.984
Data Source: STRINGDB
IFI35
Tbio
Novelty: 0.04309126
Score: 0.984
Data Source: STRINGDB
OAS2
Tbio
Family: Enzyme
Novelty: 0.01673393
Score: 0.983
Data Source: STRINGDB
IFITM2
Tbio
Novelty: 0.02496648
Score: 0.983
Data Source: STRINGDB
IFIT1
Tbio
Novelty: 0.00562299
Score: 0.979
Data Source: STRINGDB
IFIT3
Tbio
Novelty: 0.00568113
Score: 0.977
Data Source: STRINGDB
OAS1
Tbio
Family: Enzyme
Novelty: 0.00532331
Score: 0.975
Data Source: STRINGDB
CD81
Tchem
Novelty: 0.00111328
Score: 0.975
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  204.50

PubMed score by year
PubTator Score  102

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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