Tbio UNG Uracil-DNA glycosylase

Protein Summary

Description

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• P13051
• A8K5M6
• B2R8Y1
• O00637
• O00719
• Q93028
• UDG

Gene Name

• UNG

Ensembl ID

• ENST00000242576
• ENSP00000242576
• ENSG00000076248
• ENST00000336865
• ENSP00000337398

Symbol

• DGU
• UNG1
• UNG15
• DGU
• UDG
• UNG1
• UNG2
• HIGM4
• HIGM5
• UNG15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.96
transcription factor perturbation	0.84
PubMedID	0.82
disease	0.79
hub protein	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 405.97   (req: < 5)

Gene RIFs: 90   (req: <= 3)

Antibodies: 459   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 405.97   (req: >= 5)

Gene RIFs: 90   (req: > 3)

Antibodies: 459   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0