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Tbio
LYL1
Protein lyl-1

Protein Summary
Description
This gene represents a basic helix-loop-helix transcription factor. The encoded protein may play roles in blood vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264824
  • ENSP00000264824
  • ENSG00000104903

Symbol
  • BHLHA18
  • bHLHa18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.82
gene perturbation
0.79
cell type or tissue
0.76
PubMedID
0.71
tissue sample
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.99   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.99   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
TCF3
Tbio
Family:  TF
Novelty:  0.00112675
Score:  0.959
Data Source:  STRINGDB
LMO2
Tbio
Novelty:  0.0038279
Score:  0.894
Data Source:  STRINGDB
LMO1
Tbio
Novelty:  0.01670419
Score:  0.812
Data Source:  STRINGDB
LDB1
Tbio
Novelty:  0.01110112
Score:  0.756
Data Source:  STRINGDB
LDB2
Tbio
Novelty:  0.01621438
Score:  0.728
Data Source:  STRINGDB
TLX1
Tbio
Family:  TF
Novelty:  0.00619542
Score:  0.721
Data Source:  STRINGDB
GFI1B
Tbio
Family:  TF
Novelty:  0.01511971
Score:  0.707
Data Source:  STRINGDB
GATA2
Tbio
Family:  TF
Novelty:  0.00153967
Score:  0.687
Data Source:  STRINGDB
TLX3
Tbio
Family:  TF
Novelty:  0.01152722
Score:  0.679
Data Source:  STRINGDB
SPI1
Tbio
Family:  TF
Novelty:  0.00064309
Score:  0.672
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
4
4
88.4
monocyte count
2
2
2
86.8
platelet crit
1
2
2
77.6
self reported educational attainment
4
4
4
5.9
76.5
mean platelet volume
2
2
2
76.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
4
88.4
monocyte count
2
86.8
platelet crit
2
77.6
self reported educational attainment
4
5.9
76.5
mean platelet volume
2
76.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
LYL1, basic helix-loop-helix family member
718185
Mouse
MGI:96891
17095
Rat
RGD:1359244
304663
Cow
LYL1, basic helix-loop-helix family member
VGNC:31097
615458
Opossum
LYL1, basic helix-loop-helix family member
100027334
Species
Name
OMA
EggNOG
Inparanoid
Macaque
LYL1, basic helix-loop-helix family member
Mouse
Rat
Cow
LYL1, basic helix-loop-helix family member
Opossum
LYL1, basic helix-loop-helix family member
Publication Statistics
PubMed Score 42.99
PubMed score by year
PubTator Score 28.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title