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Tbio
XRCC6
X-ray repair cross-complementing protein 6

Protein Summary
Description
Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dR ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359308
  • ENSP00000352257
  • ENSG00000196419
  • ENST00000360079
  • ENSP00000353192
  • ENST00000402580
  • ENSP00000384941
  • ENST00000405878
  • ENSP00000384257

Symbol
  • G22P1
  • ML8
  • KU70
  • TLAA
  • CTC75
  • CTCBF
  • G22P1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
kinase perturbation
1
molecular function
1
protein complex
1
disease perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 722.07   (req: < 5)
Gene RIFs: 173   (req: <= 3)
Antibodies: 1207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 722.07   (req: >= 5)
Gene RIFs: 173   (req: > 3)
Antibodies: 1207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
91
self reported educational attainment
1
1
1
81.2
intelligence
1
1
0
6.6
81
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
91
self reported educational attainment
1
81.2
intelligence
0
6.6
81
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
2-LTR circle formation (R-HSA-164843)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
2-LTR circle formation
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Disease
Name
Explore in Pharos
Explore in Source
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
DNA Double-Strand Break Repair
DNA Repair
Disease
Gene Ontology Terms (47)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (390)
1 – 10 of 390
APLF
Tbio
Novelty: 0.01347476
p_int: 0.999999999
p_ni: 1e-9
Score: 0.992
Data Source: BioPlex,STRINGDB
WRN
Tbio
Family: Enzyme
Novelty: 0.00163164
p_int: 0.999999985
p_ni: 1.2e-8
p_wrong: 3e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
PARP2
Tclin
Family: Enzyme
Novelty: 0.00545618
p_int: 0.999935167
p_ni: 0.000064832
Score: 0.942
Data Source: BioPlex,STRINGDB
XPC
Tbio
Novelty: 0.00775175
p_int: 0.999015165
p_ni: 0.000984835
Score: 0.982
Data Source: BioPlex,STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
p_int: 0.998953002
p_ni: 0.001046998
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
LIG3
Tbio
Family: Enzyme
Novelty: 0.00809038
p_int: 0.998437614
p_ni: 0.001562386
Score: 0.951
Data Source: BioPlex,STRINGDB
XRCC5
Tbio
Novelty: 0.00150735
p_int: 0.997223271
p_ni: 0.002776729
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SUPT16H
Tbio
Family: Enzyme
Novelty: 0.01026868
p_int: 0.996647744
p_ni: 0.003352256
Score: 0.803
Data Source: BioPlex,STRINGDB
PARP1
Tclin
Family: Enzyme
Novelty: 0.00033016
p_int: 0.979686271
p_ni: 0.020313729
Score: 0.978
Data Source: BioPlex,STRINGDB
XRCC1
Tbio
Novelty: 0.00084203
p_int: 0.977497961
p_ni: 0.022502039
p_wrong: 1e-9
Score: 0.965
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  722.07

PubMed score by year
PubTator Score  441.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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