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Tbio
XRCC6
X-ray repair cross-complementing protein 6

Protein Summary
Description
Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dR ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359308
  • ENSP00000352257
  • ENSG00000196419
  • ENST00000360079
  • ENSP00000353192
  • ENST00000402580
  • ENSP00000384941
  • ENST00000405878
  • ENSP00000384257

Symbol
  • G22P1
  • ML8
  • KU70
  • TLAA
  • CTC75
  • CTCBF
  • G22P1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
kinase perturbation
1
molecular function
1
protein complex
1
disease perturbation
0.97


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 722.07   (req: < 5)
Gene RIFs: 173   (req: <= 3)
Antibodies: 1207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 722.07   (req: >= 5)
Gene RIFs: 173   (req: > 3)
Antibodies: 1207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
91
self reported educational attainment
1
1
1
81.2
intelligence
1
1
0
6.6
81
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
91
self reported educational attainment
1
81.2
intelligence
0
6.6
81
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
X-ray repair cross complementing 6
707975
Mouse
MGI:95606
14375
Rat
RGD:2643
25019
Dog
X-ray repair cross complementing 6
VGNC:48470
474485
Horse
X-ray repair cross complementing 6
VGNC:25084
100070684
Species
Name
OMA
EggNOG
Inparanoid
Macaque
X-ray repair cross complementing 6
Mouse
Rat
Dog
X-ray repair cross complementing 6
Horse
X-ray repair cross complementing 6
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
2-LTR circle formation (R-HSA-164843)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
2-LTR circle formation
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Disease
Name
Explore in Pharos
Explore in Source
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
DNA Double-Strand Break Repair
DNA Repair
Disease
Gene Ontology Terms (47)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (390)
1 – 10 of 390
APLF
Tbio
Novelty: 0.01347476
p_int: 0.999999999
p_ni: 1e-9
Score: 0.992
Data Source: BioPlex,STRINGDB
WRN
Tbio
Family: Enzyme
Novelty: 0.00163164
p_int: 0.999999985
p_ni: 1.2e-8
p_wrong: 3e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
PARP2
Tclin
Family: Enzyme
Novelty: 0.00545618
p_int: 0.999935167
p_ni: 0.000064832
Score: 0.942
Data Source: BioPlex,STRINGDB
XPC
Tbio
Novelty: 0.00775175
p_int: 0.999015165
p_ni: 0.000984835
Score: 0.982
Data Source: BioPlex,STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
p_int: 0.998953002
p_ni: 0.001046998
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
LIG3
Tbio
Family: Enzyme
Novelty: 0.00809038
p_int: 0.998437614
p_ni: 0.001562386
Score: 0.951
Data Source: BioPlex,STRINGDB
XRCC5
Tbio
Novelty: 0.00150735
p_int: 0.997223271
p_ni: 0.002776729
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SUPT16H
Tbio
Family: Enzyme
Novelty: 0.01026868
p_int: 0.996647744
p_ni: 0.003352256
Score: 0.803
Data Source: BioPlex,STRINGDB
PARP1
Tclin
Family: Enzyme
Novelty: 0.00033016
p_int: 0.979686271
p_ni: 0.020313729
Score: 0.978
Data Source: BioPlex,STRINGDB
XRCC1
Tbio
Novelty: 0.00084203
p_int: 0.977497961
p_ni: 0.022502039
p_wrong: 1e-9
Score: 0.965
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  722.07

PubMed score by year
PubTator Score  441.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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