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Tchem
PEPD
Xaa-Pro dipeptidase

Protein Summary
Description
Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen. This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244137
  • ENSP00000244137
  • ENSG00000124299
  • ENST00000397032
  • ENSP00000380226
  • ENST00000436370
  • ENSP00000391890

Symbol
  • PRD
  • PROLIDASE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
histone modification site profile
0.89
kinase perturbation
0.76
disease perturbation
0.74
transcription factor binding site profile
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 743.73   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 743.73   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
5
2
9
99.1
sex hormone-binding globulin measurement
6
3
6
98.8
5
4
2
1.1
97.6
waist-hip ratio
4
1
4
96.9
adiponectin measurement
4
3
4
95.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
9
99.1
sex hormone-binding globulin measurement
6
98.8
2
1.1
97.6
waist-hip ratio
4
96.9
adiponectin measurement
4
95.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidase D
VGNC:13304
455932
Macaque
peptidase D [Source:HGNC Symbol;Acc:HGNC:8840]
Mouse
MGI:97542
18624
Dog
peptidase D
VGNC:44419
476493
Horse
peptidase D
VGNC:21311
100056540
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidase D
Macaque
peptidase D [Source:HGNC Symbol;Acc:HGNC:8840]
Mouse
Dog
peptidase D
Horse
peptidase D
Protein Structure (16 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P12955-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (109)
1 – 10 of 109
FAAH2
Tchem
Family: Enzyme
Novelty: 0.06197067
Score: 0.804
Data Source: STRINGDB
PGM2
Tbio
Family: Enzyme
Novelty: 0.00922421
Score: 0.768
Data Source: STRINGDB
STK16
Tchem
Family: Kinase
Novelty: 0.01499094
Score: 0.754
Data Source: STRINGDB
APOC1
Tbio
Novelty: 0.00338935
Score: 0.746
Data Source: STRINGDB
MDH1
Tbio
Family: Enzyme
Novelty: 0.00203876
Score: 0.728
Data Source: STRINGDB
CNDP2
Tbio
Family: Enzyme
Novelty: 0.00157228
Score: 0.725
Data Source: STRINGDB
APOC2
Tbio
Novelty: 0.0015496
Score: 0.715
Data Source: STRINGDB
FAAH
Tchem
Family: Enzyme
Novelty: 0.00162361
Score: 0.689
Data Source: STRINGDB
ERCC2
Tbio
Family: Enzyme
Novelty: 0.00240155
Score: 0.688
Data Source: STRINGDB
LDHB
Tchem
Family: Enzyme
Novelty: 0.00242213
Score: 0.675
Data Source: STRINGDB
Publication Statistics
PubMed Score  743.73

PubMed score by year
PubTator Score  466.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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