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Tclin
SRC
Proto-oncogene tyrosine-protein kinase Src

Protein Summary
Description
Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358208
  • ENSP00000350941
  • ENSG00000197122
  • ENST00000373558
  • ENSP00000362659
  • ENST00000373567
  • ENSP00000362668
  • ENST00000373578
  • ENSP00000362680

Symbol
  • SRC1
  • ASV
  • SRC1
  • THC6
  • c-SRC
  • p60-Src
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
drug
1
hub protein
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11839.77   (req: < 5)
Gene RIFs: 717   (req: <= 3)
Antibodies: 1782   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11839.77   (req: >= 5)
Gene RIFs: 717   (req: > 3)
Antibodies: 1782   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 132
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 828
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7