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Tbio
MLN
Promotilin

Protein Summary
Description
Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle. This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266003
  • ENSP00000266003
  • ENSG00000096395
  • ENST00000430124
  • ENSP00000388825
  • ENST00000507738
  • ENSP00000425467
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.79
disease
0.61
pathway
0.5
tissue
0.5
phenotype
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1003.87   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1003.87   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (199)
1 – 10 of 199
MLNR
Tchem
Family:  GPCR
Novelty:  0.0048579
Score:  0.994
Data Source:  Reactome,STRINGDB
GAST
Tbio
Novelty:  0.00011795
Score:  0.985
Data Source:  STRINGDB
CCK
Tbio
Novelty:  0.00012268
Score:  0.974
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.972
Data Source:  STRINGDB
GHSR
Tclin
Family:  GPCR
Novelty:  0.00165638
Score:  0.968
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.965
Data Source:  STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.965
Data Source:  STRINGDB
GPR39
Tchem
Family:  GPCR
Novelty:  0.01244607
Score:  0.963
Data Source:  STRINGDB
GRP
Tbio
Novelty:  0.00034247
Score:  0.962
Data Source:  STRINGDB
NMU
Tbio
Novelty:  0.00326109
Score:  0.958
Data Source:  STRINGDB
Pathways (14)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
88.7
phosphorus measurement
2
2
2
70.4
platelet count
1
1
1
69.8
3
2
1
1.1
66.6
self reported educational attainment
2
2
2
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
88.7
phosphorus measurement
2
70.4
platelet count
1
69.8
1
1.1
66.6
self reported educational attainment
2
56.4
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
motilin
VGNC:11118
747107
Macaque
motilin
574099
Dog
motilin
481748
Horse
motilin [Source:HGNC Symbol;Acc:HGNC:7141]
Cow
motilin
VGNC:31505
280860
Species
Name
OMA
EggNOG
Inparanoid
Chimp
motilin
Macaque
motilin
Dog
motilin
Horse
motilin [Source:HGNC Symbol;Acc:HGNC:7141]
Cow
motilin
Publication Statistics
PubMed Score 1003.87
PubMed score by year
PubTator Score 489.57
PubTator score by year