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Tbio
DEFA4
Neutrophil defensin 4

Protein Summary
Description
Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production. Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297435
  • ENSP00000297435
  • ENSG00000164821
  • ENST00000642522
  • ENSP00000493844
  • ENSG00000285318

Symbol
  • DEF4
  • HP4
  • DEF4
  • HP-4
  • HNP-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
PubMedID
0.57
cellular component
0.56
metabolite
0.45
small molecule perturbation
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.96   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.96   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
7
8
98.7
monocyte percentage of leukocytes
2
7
8
98.7
basophil percentage of leukocytes
2
8
8
97.9
basophil percentage of leukocytes
2
8
8
97.9
basophil count
2
7
8
97.7
Items per page:
1 – 5 of 18
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
8
98.7
monocyte percentage of leukocytes
8
98.7
basophil percentage of leukocytes
8
97.9
basophil percentage of leukocytes
8
97.9
basophil count
8
97.7
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defensin, alpha 4, corticostatin
463971
Rat
RGD:727857
286958
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defensin, alpha 4, corticostatin
Rat
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P12838-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Alpha-defensins (R-HSA-1462054)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Alpha-defensins
Reactome
Antimicrobial peptides
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Alpha-defensins
Antimicrobial peptides
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (20)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (108)
1 – 10 of 108
ELANE
Tclin
Family:  Enzyme
Novelty:  0.00026112
Score:  0.987
Data Source:  STRINGDB
BPI
Tbio
Novelty:  0.00229665
Score:  0.984
Data Source:  STRINGDB
CAMP
Tbio
Novelty:  0.00064433
Score:  0.98
Data Source:  STRINGDB
DEFA3
Tbio
Novelty:  0.04840173
Score:  0.977
Data Source:  STRINGDB
DEFB1
Tbio
Novelty:  0.00144458
Score:  0.964
Data Source:  STRINGDB
PGLYRP1
Tbio
Novelty:  0.00231527
Score:  0.964
Data Source:  STRINGDB
LTF
Tbio
Novelty:  0.00114254
Score:  0.963
Data Source:  STRINGDB
MMP8
Tchem
Family:  Enzyme
Novelty:  0.00105859
Score:  0.959
Data Source:  STRINGDB
OLFM4
Tbio
Novelty:  0.01048505
Score:  0.955
Data Source:  STRINGDB
CRISP3
Tbio
Novelty:  0.017452
Score:  0.949
Data Source:  STRINGDB
Publication Statistics
PubMed Score  19.96

PubMed score by year
PubTator Score  43.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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