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Tbio
CDH1
Cadherin-1

Protein Summary
Description
Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261769
  • ENSP00000261769
  • ENSG00000039068
  • ENST00000422392
  • ENSP00000414946

Symbol
  • CDHE
  • UVO
  • UVO
  • CDHE
  • ECAD
  • LCAM
  • Arc-1
  • BCDS1
  • CD324
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
chemical
0.99
cellular component
0.94
protein domain
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9252.5   (req: < 5)
Gene RIFs: 1581   (req: <= 3)
Antibodies: 2688   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9252.5   (req: >= 5)
Gene RIFs: 1581   (req: > 3)
Antibodies: 2688   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
4
97.8
reticulocyte measurement
3
3
3
95.3
reticulocyte count
6
3
6
94.3
HbA1c measurement
2
3
3
84.3
mean corpuscular hemoglobin concentration
1
1
1
82.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
97.8
reticulocyte measurement
3
95.3
reticulocyte count
6
94.3
HbA1c measurement
3
84.3
mean corpuscular hemoglobin concentration
1
82.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cadherin 1
VGNC:8961
468009
Macaque
cadherin 1
704387
Mouse
MGI:88354
12550
Rat
RGD:69279
83502
Dog
cadherin 1
VGNC:53314
442858
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cadherin 1
Macaque
cadherin 1
Mouse
Rat
Dog
cadherin 1
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P12830-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (70)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Adherens junctions interactions
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cell adhesion proteins
Reactome
Apoptotic cleavage of cellular proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Adherens junctions interactions
Apoptosis
Apoptotic cleavage of cell adhesion proteins
Apoptotic cleavage of cellular proteins
Gene Ontology Terms (51)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (833)
1 – 10 of 833
CTNNA3
Tbio
Novelty:  0.01472452
p_int:  0.999999802
p_ni:  4.4e-8
p_wrong:  1.54e-7
Score:  0.908
Data Source:  BioPlex,STRINGDB
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  0.999999122
p_ni:  8.78e-7
Data Source:  BioPlex
CTNND1
Tbio
Novelty:  0.00335459
p_int:  0.999822516
p_ni:  0.00006434
p_wrong:  0.000113145
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PCDHGC3
Tbio
Novelty:  0.07203024
p_int:  0.751930881
p_ni:  0.000787222
p_wrong:  0.247281897
Score:  0.187
Data Source:  BioPlex,STRINGDB
FER
Tclin
Family:  Kinase
Novelty:  0.01531184
Score:  0.999
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.999
Data Source:  Reactome,STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.999
Data Source:  STRINGDB
SNAI1
Tbio
Family:  TF
Novelty:  0.00040495
Score:  0.997
Data Source:  STRINGDB
ZEB1
Tbio
Family:  TF
Novelty:  0.00085257
Score:  0.997
Data Source:  STRINGDB
SNAI2
Tbio
Family:  TF
Novelty:  0.00096495
Score:  0.996
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9252.50

PubMed score by year
PubTator Score  6804.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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