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Tbio
MYL4
Myosin light chain 4

Protein Summary
Description
Regulatory light chain of myosin. Does not bind calcium. Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354968
  • ENSP00000347055
  • ENSG00000198336
  • ENST00000393450
  • ENSP00000377096
  • ENST00000572316
  • ENSP00000461570

Symbol
  • MLC1
  • GT1
  • ALC1
  • AMLC
  • PRO1957
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
disease perturbation
0.83
PubMedID
0.78
small molecule perturbation
0.69
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.27   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.27   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
MYH6
Tbio
Novelty:  0.00058671
Score:  0.982
Data Source:  Reactome,STRINGDB
MYH3
Tbio
Novelty:  0.00544794
Score:  0.981
Data Source:  Reactome,STRINGDB
MYH8
Tbio
Novelty:  0.01020559
Score:  0.981
Data Source:  Reactome,STRINGDB
TNNI1
Tbio
Novelty:  0.01639536
Score:  0.972
Data Source:  STRINGDB
TNNI3
Tbio
Novelty:  0.00020053
Score:  0.97
Data Source:  STRINGDB
TTN
Tbio
Family:  Kinase
Novelty:  0.00040356
Score:  0.969
Data Source:  Reactome,STRINGDB
TNNT2
Tbio
Novelty:  0.00044568
Score:  0.968
Data Source:  STRINGDB
TNNI2
Tbio
Novelty:  0.02772952
Score:  0.966
Data Source:  STRINGDB
TNNT1
Tbio
Novelty:  0.00072003
Score:  0.965
Data Source:  STRINGDB
MYLK
Tchem
Family:  Kinase
Novelty:  0.00102277
Score:  0.964
Data Source:  STRINGDB
Pathways (7)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
3
3
64.6
platelet count
2
2
2
59.6
serum non-albumin protein measurement
1
2
2
47.6
serum urea measurement
1
1
1
45
eosinophil count
1
1
1
33.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
64.6
platelet count
2
59.6
serum non-albumin protein measurement
2
47.6
serum urea measurement
1
45
eosinophil count
1
33.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 4
VGNC:9450
454814
Macaque
myosin light chain 4
717354
Mouse
MGI:97267
17896
Rat
RGD:1591197
688228
Dog
myosin light chain 4 [Source:HGNC Symbol;Acc:HGNC:7585]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 4
Macaque
myosin light chain 4
Mouse
Rat
Dog
myosin light chain 4 [Source:HGNC Symbol;Acc:HGNC:7585]
Publication Statistics
PubMed Score 116.27
PubMed score by year
PubTator Score 32.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title