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Tclin
ACE
Angiotensin-converting enzyme

Protein Classes
Protein Summary
Description
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encod ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290863
  • ENSP00000290863
  • ENSG00000159640
  • ENST00000290866
  • ENSP00000290866
  • ENST00000413513
  • ENSP00000392247

Symbol
  • DCP
  • DCP1
  • DCP
  • ACE1
  • DCP1
  • CD143
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
molecular function
0.94
disease
0.91
chemical
0.85
biological term
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20181.83   (req: < 5)
Gene RIFs: 1441   (req: <= 3)
Antibodies: 788   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20181.83   (req: >= 5)
Gene RIFs: 1441   (req: > 3)
Antibodies: 788   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 301
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 19
Protein Data Bank (41)
1 – 5 of 41
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (77)
Metabolism of Angiotensinogen to Angiotensins (R-HSA-2022377)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of Angiotensinogen to Angiotensins
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Metabolism of Angiotensinogen to Angiotensins
Metabolism of proteins
Peptide hormone metabolism
Gene Ontology Terms (56)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (291)
1 – 10 of 291
METTL9
Tdark
Family: Enzyme
Novelty: 0.16438356
p_int: 0.988621254
p_ni: 2.63e-7
p_wrong: 0.011378484
Data Source: BioPlex
AGT
Tbio
Novelty: 0.00056146
Score: 0.996
Data Source: Reactome,STRINGDB
REN
Tclin
Family: Enzyme
Novelty: 0.00002857
Score: 0.959
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00008572
Score: 0.95
Data Source: STRINGDB
AGTR1
Tclin
Family: GPCR
Novelty: 0.00032594
Score: 0.928
Data Source: STRINGDB
AGTR2
Tchem
Family: GPCR
Novelty: 0.00064305
Score: 0.926
Data Source: STRINGDB
NOS3
Tchem
Family: Enzyme
Novelty: 0.00010217
Score: 0.878
Data Source: STRINGDB
MDK
Tchem
Novelty: 0.00179902
Score: 0.871
Data Source: STRINGDB
SERPINE1
Tchem
Novelty: 0.00020589
Score: 0.854
Data Source: STRINGDB
MME
Tclin
Family: Enzyme
Novelty: 0.00025418
Score: 0.843
Data Source: STRINGDB
Publication Statistics
PubMed Score  20181.83

PubMed score by year
PubTator Score  16359.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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