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Tclin
ACE
Angiotensin-converting enzyme

Protein Summary
Description
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encod ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290863
  • ENSP00000290863
  • ENSG00000159640
  • ENST00000290866
  • ENSP00000290866
  • ENST00000413513
  • ENSP00000392247

Symbol
  • DCP
  • DCP1
  • DCP
  • ACE1
  • DCP1
  • CD143
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
molecular function
0.94
disease
0.91
chemical
0.85
biological term
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29269.93   (req: < 5)
Gene RIFs: 1441   (req: <= 3)
Antibodies: 788   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29269.93   (req: >= 5)
Gene RIFs: 1441   (req: > 3)
Antibodies: 788   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 301
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 19
Approved Drugs (19)
1 – 10 of 19
captopril
chemical structure image
losartan
chemical structure image
enalapril
chemical structure image
enalaprilat
chemical structure image
trandolapril
chemical structure image
ramipril
chemical structure image
lisinopril
chemical structure image
cilazapril
chemical structure image
benazepril
chemical structure image
spirapril
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
angiotensin converting enzyme activity measurement
1
1
0
16.2
93.7
blood metabolite measurement
2
3
6
92.9
serum metabolite measurement
2
3
8
92.8
2
2
2
90.6
metabolite measurement
1
1
1
81.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
angiotensin converting enzyme activity measurement
0
16.2
93.7
blood metabolite measurement
6
92.9
serum metabolite measurement
8
92.8
2
90.6
metabolite measurement
1
81.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
angiotensin I converting enzyme
VGNC:51632
449567
Mouse
MGI:87874
11421
Rat
RGD:2493
24310
Dog
angiotensin I converting enzyme
610668
Horse
angiotensin I converting enzyme
100064801
Species
Name
OMA
EggNOG
Inparanoid
Chimp
angiotensin I converting enzyme
Mouse
Rat
Dog
angiotensin I converting enzyme
Horse
angiotensin I converting enzyme
Protein Data Bank (41)
1 – 5 of 41
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (77)
Metabolism of Angiotensinogen to Angiotensins (R-HSA-2022377)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of Angiotensinogen to Angiotensins
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Metabolism of Angiotensinogen to Angiotensins
Metabolism of proteins
Peptide hormone metabolism
Gene Ontology Terms (56)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (291)
1 – 10 of 291
METTL9
Tdark
Family: Enzyme
Novelty: 0.20589257
p_int: 0.988621254
p_ni: 2.63e-7
p_wrong: 0.011378484
Data Source: BioPlex
AGT
Tbio
Novelty: 0.00049613
Score: 0.996
Data Source: Reactome,STRINGDB
REN
Tclin
Family: Enzyme
Novelty: 0.00002435
Score: 0.959
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.95
Data Source: STRINGDB
AGTR1
Tclin
Family: GPCR
Novelty: 0.00033439
Score: 0.928
Data Source: STRINGDB
AGTR2
Tchem
Family: GPCR
Novelty: 0.00064774
Score: 0.926
Data Source: STRINGDB
NOS3
Tchem
Family: Enzyme
Novelty: 0.00012407
Score: 0.878
Data Source: STRINGDB
MDK
Tchem
Novelty: 0.00145301
Score: 0.871
Data Source: STRINGDB
SERPINE1
Tchem
Novelty: 0.00017629
Score: 0.854
Data Source: STRINGDB
MME
Tclin
Family: Enzyme
Novelty: 0.00019144
Score: 0.843
Data Source: STRINGDB
Publication Statistics
PubMed Score  29269.93

PubMed score by year
PubTator Score  16359.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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