Tclin ACE Angiotensin-converting enzyme

Protein Summary

Description

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• P12821
• B0LPF0
• B4DXI3
• E7EU16
• P22966
• Q53YX9
• Q59GY8
• Q7M4L4
• ACE

Gene Name

• ACE

Ensembl ID

• ENST00000290863
• ENSP00000290863
• ENSG00000159640
• ENST00000290866
• ENSP00000290866
• ENST00000413513
• ENSP00000392247

Symbol

• DCP
• DCP1
• DCP
• ACE1
• DCP1
• CD143

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
molecular function	0.94
disease	0.91
chemical	0.85
biological term	0.8

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Angiotensin-converting Enzyme

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Angiotensin-converting Enzyme

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36046.16   (req: < 5)

Gene RIFs: 1666   (req: <= 3)

Antibodies: 788   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36046.16   (req: >= 5)

Gene RIFs: 1666   (req: > 3)

Antibodies: 788   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 431

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 19